HDL metabolism in Diabetes Mellitus-The clinical role of HDL receptor SR-BI/CLA-1-

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591081
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kagawa University
• Principal Investigator: MURAO Koji Kagawa University, 医学部附属病院, 講師 (20291982)
• Co-Investigator(Kenkyū-buntansha): IMACHI Hitomi 香川大学, 医学部・附属病院, 助教 (80380187) ; ISHIDA Toshihiko 香川大学, 医学部, 教授 (50159737) ; OHMORI Koji 香川大学, 医学部, 准教授 (00263913)
• Project Period (FY): 2008 – 2010
• Keywords: 脂質異常症 / 糖尿病

Research Abstract

Hyperglycemia suppressed the expression of HDL receptor SR-BI/CLA-1 via the activation of p38-MAPK pathway in Diabetes Mellitus. In diabetes mellitus, hyperglycemia stimulated atherosclerosis by inhibition of HDL metabolism. On the other hand, TZD stimulated the expression of SR-BI/CLA-1 in liver via the activation of PPARs.

Research Products

• [Journal Article] Exendin-4 regulates GLUT2 expression via the CaMKK/CaMKIV pathway in a pancreatic β-cell line. (2011)
  • Author(s): Chen K, Yu X, Murao K, Imachi H, Li J, Muraoka T, Masugata H, Zhang GX, Kobayashi R, Ishida T, Tokumitsu H.
  • Journal Title: Metabolism. 60(4) Pages: 579-585
  • Peer Reviewed
• [Journal Article] Prolactin regulatory element-binding protein involved in cAMP-mediated suppression of adiponectin gene. (2010)
  • Author(s): Li J, Murao K, Imachi H, Yu X, Muraoka T, Kim JB, Ishida T.
  • Journal Title: J Cell Mol Med. 14(6A) Pages: 1294-1302
  • Peer Reviewed
• [Journal Article] Menin, a product of the MENI gene, binds to estrogen receptor to enhance its activity in breast cancer cells : possibility of a novel predictive factor for tamoxifen resistance. (2010)
  • Author(s): Imachi H, Murao K, Dobashi H, Bhuyan MM, Cao X, Kontani K, Niki S, Murazawa C, Nakajima H, Kohno N, Yamashita H, Iwase H, Hayashi S, Ishida T, Yamauchi A.
  • Journal Title: Breast Cancer Res Treat. 122(2) Pages: 395-407
  • Peer Reviewed
• [Journal Article] Exendin-4 regulates pancreatic ABCA1 transcription via CaMKK/CaMKIV pathway. (2010)
  • Author(s): Li J, Murao K, Imachi H, Masugata H, Iwama H, Tada S, Zhang GX, Kobayashi R, Ishida T, Tokumitsu H.
  • Journal Title: J Cell Mol Med. 14(5) Pages: 1083-1087
  • Peer Reviewed
• [Journal Article] Hyperglycemia suppresses ABCA1 expression in vascular smooth muscle cells. (2010)
  • Author(s): Yu X, Murao K, Imachi H, Li J, Nishiuchi T, Hosomi N, Masugata H, Zhang GX, Iwama H, Ishida T.
  • Journal Title: Horm Metab Res. 42(4) Pages: 241-246
  • Peer Reviewed
• [Journal Article] Scavenger receptor class BI mediates the anti-apoptotic effect of erythropoietin. (2010)
  • Author(s): Nishiuchi T, Murao K, Imachi H, Yu X, Dobashi H, Haba R, Ishida T.
  • Journal Title: Ann Med. 42(2) Pages: 151-160
  • Peer Reviewed
• [Journal Article] Transcriptional factor prolactin regulatory element-binding protein-mediated gene transcription of ABCA1 via 3',5'-cyclic adenosine-5'-monophosphate. (2010)
  • Author(s): Nishiuchi Y, Murao K, Imachi H, Nishiuchi T, Iwama H, Ishida T.
  • Journal Title: Atherosclerosis. 212(2) Pages: 418-425
  • Peer Reviewed
• [Journal Article] Human scavenger receptor class B type 1 is regulated by activators of peroxisome proliferators-activated receptor-gamma in hepatocytes. (2009)
  • Author(s): Ahmed RA, Murao K, Imachi H, Yu X, Li J, Wong NC, Ishida T.
  • Journal Title: Endocrine. 35(2) Pages: 233-242
  • Peer Reviewed
• [Journal Article] PREB regulates transcription of pancreatic glucokinase in response to glucose and cAMP. (2009)
  • Author(s): Muraoka T, Murao K, Imachi H, Yu X, Li J, Wong NC, Ishida T.
  • Journal Title: J Cell Mol Med. 13(8B) Pages: 2386-2395
  • Peer Reviewed
• [Journal Article] The transcriptional factor PREB mediates MCP-1 transcription induced by cytokines in human vascular endothelial cells. (2009)
  • Author(s): Murao K, Imachi H, Yu X, Muraoka T, Hosami N, Dobashi H, Ishida T.
  • Journal Title: Atherosclerosis. 207(1) Pages: 45-50
  • Peer Reviewed
• [Journal Article] Exendin-4 regulates glucokinase expression by CaMKK/CaMKIV pathway in pancreatic beta-cell line. (2009)
  • Author(s): Murao K, Li J, Imachi H, Muraoka T, Masugata H, Zhang GX, Kobayashi R, Ishida T, Tokumitsu H.
  • Journal Title: Diabetes Obes Metab. 11(10) Pages: 939-946
  • Peer Reviewed
• [Journal Article] Hyperglycemia suppresses hepatic scavenger receptor class B type I expression. (2008)
  • Author(s): Murao K, Yu X, Imachi H, Cao WM, Chen K, Matsumoto K, Nishiuchi T, Wong NC, Ishida T.
  • Journal Title: Am J Physiol Endocrinol Metab. 294(1) Pages: E78-87
  • Peer Reviewed
• [Journal Article] Interferon alpha decreases expression of human scavenger receptor class BI, a possible HCV receptor in hepatocytes. (2008)
  • Author(s): Murao K, Imachi H, Yu X, Cao WM, Nishiuchi T, Chen K, Li J, Ahmed RA, Wong NC, Ishida T.
  • Journal Title: Gut. 57(5) Pages: 664-671
  • Peer Reviewed
• [Journal Article] The transcriptional factor prolactin regulatory element-binding protein mediates the gene transcription of adrenal scavenger receptor class B type I via 3',5'-cyclic adenosine 5'-monophosphate. (2008)
  • Author(s): Murao K, Imachi H, Yu X, Cao WM, Muraoka T, Dobashi H, Hosomi N, Haba R, Iwama H, Ishida T.
  • Journal Title: Endocrinology. 149(12) Pages: 6103-6112
  • Peer Reviewed
• [Journal Article] The prolactin regulatory element-binding regulates of the 11beta-hydroxylase gene. (2008)
  • Author(s): Imachi H, Murao K, Cao WM, Muraoka T, Nishiuchi T, Dobashi H, Hosomi N, Iwama H, Ishida T.
  • Journal Title: Biochem Biophys Res Commun. 21;376(3) Pages: 531-535
  • Peer Reviewed
• [Presentation] 糖尿病におけるHDL代謝(コレステロール逆転送系)異常 (2009)
  • Author(s): 村尾孝児、井町仁美、村岡都美江、石田俊彦
  • Organizer: 第52回日本糖尿病学会学術総会,シンポジウム
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-04-27
• [Book] 内分泌代謝テキストブック (2010)
  • Author(s): 村尾孝児, 他
  • Publisher: Springer印刷中