2010 Fiscal Year Final Research Report
Roles of Wnt signaling pathway in progression of vascular calcification
| Project/Area Number |
20591082
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Osaka City University |
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Principal Investigator |
SHIOI Atsushi Osaka City University, 大学院・医学研究科, 講師 (90260801)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUMOTO Shinya 大阪市立大学, 大学院・医学研究科, 講師 (90381996)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 骨 / カルシウム代謝異常 |
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| Research Abstract |
We investigated the roles of Wnt signaling pathway in the development of atherosclerosis and vascular calcification. This study clarified that Wnt signaling pathway is activated in atherosclerotic plaques including calcified lesions and that this pathway plays an important role in acquisition of osteoblastic phenotype of vascular smooth muscle cells. Activation of Wnt signaling pathway in vascular lesions may be induced by inflammatory stimuli. Moreover, cellular senescence may also contribute to the development of atherosclerosis and vascular calcification.
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[Journal Article] Fetuin-A is associated with calcified coronary artery disease.2010
Author(s)
Mori K, Ikari Y, Jono S, Emoto M, Shioi A, Koyama H, Shoji T, Ishimura E, Inaba M, Hara K, Nishizawa Y
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Journal Title
Coron Artery Dis 21
Pages: 281-285
Peer Reviewed
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[Journal Article] Receptor for advanced glycation end-product (RAGE) regulation of adiposity and adiponectin is associated with atherosclerosis in apoE-deficient mouse.2010
Author(s)
Ueno H, Koyama H, Shoji T, Monden M, Fukumoto S, Tanaka S, Otsuka Y, Mima Y, Morioka T, Mori K, Shioi A, Yamamoto H, Inaba M, Nishizawa Y
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Journal Title
Atherosclerosis 211
Pages: 431-436
Peer Reviewed
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[Journal Article] Effects of pravastatin on serum osteoprotegerin levels in patients with hypercholesterolemia and type 2 diabetes.2010
Author(s)
Mori K, Jono S, Emoto M, Kawagishi T, Yasumoto H, Konishi T, Furumitsu Y, Shioi A, Shoji T, Inaba M, Nishizawa Y
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Journal Title
Angiology 61
Pages: 86-91
Peer Reviewed
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