2010 Fiscal Year Final Research Report
Regulation of macrophage foam cell formation and atherosclerosis by novel regulatory peptides for cardiovascular system
| Project/Area Number |
20591084
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Showa University |
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Principal Investigator |
MIYAZAKI Akira Showa University, 医学部, 教授 (70253721)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Takuya 東京薬科大学, 生命科学部, 教授 (30297014)
HIRANO Tsutomu 昭和大学, 医学部, 教授 (00167610)
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| Co-Investigator(Renkei-kenkyūsha) |
SHICHIRI Masayoshi 北里大学, 医学部, 教授 (10206097)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 動脈硬化 / 血管作動性物質 / マクロファージ / 高血圧 |
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| Research Abstract |
Continuous subcutaneous infusion of urotensin II, a strong vasoconstrictor peptide, enhanced atherosclerotic lesions by 8-fold in fat-fed apoE-knockout mice. Analyses of peritoneal macrophages from urotensin II-treated mice revealed 7-fold increase in foam cell formation induced by oxidized LDL. Salusins are novel vasoregulatory peptides that derive from the same precursor. Development of atherosclerosis in apoE-KO mice was suppressed by 68% by continuous subcutaneous infusion of salusin-α but was 2.6-fold enhanced by salusin-β. Peritoneal macrophages from salusin?α-treated mice revealed 68% reduction in foam cell formation induced by oxidized LDL whereas macrophages from salusin-β-treated mice showed 2.6-fold increase in foam cell formation. Thus, urotensin II and salusins can be regarded as novel therapeutic targets for atherosclerosis.
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[Journal Article] Chronic infusin of salusin-α and salusin-β exerts opposite effects on atherosclerostic lesion development in apolipoprotein E-deficient mice.2010
Author(s)
Nagashima M, Watanabe T, Shiraishi Y, Morita R, Terasaki M, Arita S, Hongo S, Sato K, Shichiri M, Miyazaki A, Hirano T
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Journal Title
Atherosclerosis 212(1)
Pages: 70-77
Peer Reviewed
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[Journal Article] Increased plasma urotensin-II and carotid atherosclerosis are associated with vascular dementia.2009
Author(s)
Ban Y, Watanabe T, Suguro T, Matsuyama T, Iso Y, Sakai T, Sato R, Idei T, Nakano Y, Ota H, Miyazaki A, Kato N, Hirano T, Ban Y, Kobayashi Y
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Journal Title
Journal of Atherosclerosis and Thrombosis 16(3)
Pages: 179-187
Peer Reviewed
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[Journal Article] Preventive effects of heregulin-β1 on macrophage foam cell formation and atherosclerosis.2009
Author(s)
Xu G, Watanabe T, Iso Y, Koba S, Sakai T, Nagashima M, Arita S, Hongo S, Ota H, Kobayashi Y, Miyazaki A, Hirano T
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Journal Title
Circulation Research 105(5)
Pages: 500-510
Peer Reviewed
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