2010 Fiscal Year Final Research Report
Role of MLL/menin-cell cycle pathway in neuroendocrine tumorigenesis
| Project/Area Number |
20591087
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Gunma University |
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Principal Investigator |
YAMADA Masanobu Gunma University, 医学部, 講師 (90261833)
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| Project Period (FY) |
2008 – 2010
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| Keywords | MLL / p27 / 下垂体腫瘍 / オクトレオチド |
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| Research Abstract |
Menin, the product of the MEN1 gene, form a nuclear complex with mixed lineage leukemia (MLL) protein, a human histone methyltransferase and activated transcription of the p27^<Kip1> and p18^<Ink4C> genes. In multiple endocrine neoplasia type 1 (MEN1), a mutation of menin caused decreased expression of the p27^<Kip1> and p18^<Ink4C> genes and deregulated cell growth. We found that the MLL-p27^<Kip1> pathway was downregulated in the pituitary adenomas, and octreotide increased the p27^<Kip1> level, at least in part, by sequential transcriptional stimulation of the MLL and p27^<Kip1> genes through PI3K/Akt and MAPK pathways.
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[Journal Article] Attenuated expression of menin and p27 (Kip1) in an aggressive case of multiple endocrine neoplasia type 1 (MEN1) associated with an atypical prolactinoma and a malignant pancreatic endocrine tumor.2011
Author(s)
Ishida E, Yamada M, Horiguchi K, Taguchi R, Ozawa A, Shibusawa N, Hashimoto K, Satoh T, Yoshida S, Tanaka Y, Yokota M, Tosaka M, Hirato J, Yamada S, Yoshimoto Y, Mori M
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Journal Title
Peer Reviewed
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[Journal Article] Troglitazone, a ligand of peroxisome proliferator-activated receptor-{gamma}, stabilizes NUCB2 (Nesfatin) mRNA by activating the ERK1/2 pathway : isolation and characterization of the human NUCB2 gene.2010
Author(s)
Yamada M, Horiguchi K, Umezawa R, Hashimoto K, Satoh T, Ozawa A, Shibusawa N, Monden T, Okada S, Shimizu H, Mori M
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Journal Title
Endocrinology. 151
Pages: 2494-2503
Peer Reviewed
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[Journal Article] Tat-binding Protein-1, an ATPase of 19S Regulatory Particles of the 26S Proteasome, Enhances Androgen Receptor Function in Cooperation with Tat-binding Protein-1-interacting Protein/Hop2.2009
Author(s)
Satoh T, Ishizuka T, Tomaru T, Yoshino S, Nakajima Y, Hashimoto K, Shibusawa N, Monden T, Yamada M, Mori M
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Journal Title
Endocrinology 386
Pages: 697-702
Peer Reviewed
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[Journal Article] Peripheral administration of nesfatin-1 reduces food intake in mice : the leptin-independent mechanism.2009
Author(s)
Shimizu H, Oh-I S, Hashimoto K, Nakata M, Yamamoto S, Yoshida N, Eguchi H, Kato I, Inoue K, Satoh T, Okada S, Yamada M, Yada T, Mori M
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Journal Title
Endocrinology. 150
Pages: 662-671
Peer Reviewed
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[Presentation] Expression level of p18, but not p27, is reduced in thyroid tumors2009
Author(s)
Ozawa A, Yamada M, Koibuchi Y, Horiguchi J, Horiguchi K, Shibusawa N, Hashimoto K, Satoh T, Mori M
Organizer
9^<th> Asia and Oceania Thyroid Association Congress
Place of Presentation
Nagoya Japan
Year and Date
2009-11-02
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