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2010 Fiscal Year Final Research Report

Analysis of function of GABAB systems in the arcuate nucleus in energy balance

Research Project

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Project/Area Number 20591093
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionNagoya University

Principal Investigator

ARIMA Hiroshi  Nagoya University, 医学部附属病院, 講師 (50422770)

Co-Investigator(Kenkyū-buntansha) OOISO Yutaka  名古屋大学, 大学院・医学系研究科, 教授 (40203707)
Project Period (FY) 2008 – 2010
Keywords肥満、視床下部 / GABABレセプター
Research Abstract

We have made mice in which GABA_B receptor gene is knocked out exclusively in the POMC neurons using Cre-loxP system. The weight of epididymal white adipose tissues as well as body weight was increased in the knock-out mice compared to wild-type mice when they were fed a high-fat diet for 12 weeks from the age of 4 weeks. In addition, the levels of blood insulin and leptin were increased in the knockout mice compared to wild-type mice. Thus, our data suggest that GABA_B receptors in the POMC neurons play an important role in preventing the onset and progress of obesity.

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Published: 2012-01-26   Modified: 2016-04-21  

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