2010 Fiscal Year Final Research Report
Studies on the pathogenesis of autoimmune thyroid diseases : using genetically-engineered mice
| Project/Area Number |
20591099
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAGAYAMA Yuji Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (30274632)
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| Co-Investigator(Kenkyū-buntansha) |
ABIRU Norio 長崎大学, 大学院・医歯薬学総合研究科, 助教 (00380981)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 甲状腺自己免疫 / TSH受容体 / 橋本病 / バセドウ病 |
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| Research Abstract |
To scrutinize the pathogenesis of autoimmune thyroid diseases (Graves' disease and Hashimoto' thyroiditis) using genetically-engineered mice.
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[Journal Article] Current concentration of artificial radionuclides and estimated radiation doses around the Chernobyl Nuclear Power Plant, the Semipalatinsk Nuclear Testing Site, and in Nagasaki.2011
Author(s)
Taira Y, Hayashida N, Brahmanandhan GM, Nagayama Y, Yamashita S, Takahashi J, Gutevitc A, Kozlovsky A, Urazalin M, Takamura N.
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Journal Title
J Radiat Res. 52(1)
Pages: 88-95
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[Journal Article] Combined activation of innate and adaptive immunity with polyinosinic- polycytidylic acid and insulin B:9-23 self-peptide in the genetically susceptible NOD mouse : differential effects on insulitis and diabetes progression.2008
Author(s)
Fukushima K, Kobayashi M, Nagayama Y, Satoh T, Nakahara M, Kawasaki E, Yamasaki H, Ueha S, Matsushima K, Liu E, Eisenbarth GS, Eguchi K, Abiru N.
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Journal Title
Biochem Biophys Res Commun. 367(4)
Pages: 719-724
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[Journal Article] CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse.
Author(s)
Satoh T, Abiru N, Kobayashi M, Zhou H, Nakamura K, Kuriya G, Nagayama Y, Kawasaki E, Yamasaki H, Yu L, Eisenbarth GS, Araki E, Mori M, Oyadomari S, Eguchi K.
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Journal Title
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[Presentation] Granzyme B Deficiency Reduces Cyclophosphamide Induced Diabetes, But Not Spontaneous Diabetes in nonobese diabetic (NOD) mice.2009
Author(s)
Kobayashi M, Kaneko C, Abiru N, Kan Nakamura, Kuriya G, Satoh T, Kawasaki E, Yamasaki H, Nagayama Y, Eguchi K
Organizer
IDS 10
Place of Presentation
Sweden
Year and Date
20090000
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[Presentation] Loss of IL-17 does not impact on the development of diabetes, but reduces the expression of insulin autoantibodies in NOD mice.2009
Author(s)
Kuriya G, Abiru N, Nagayama Y, Nakamura K, Sato T, Kobayashi M, Kawasaki E, Yamasaki H, Iwakura Y, Eguchi K
Organizer
IDS 10
Place of Presentation
Sweden
Year and Date
20090000
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