2010 Fiscal Year Final Research Report
Identification and functional analysis of novel hypothalamic peptides
| Project/Area Number |
20591100
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Endocrinology
|
|---|
| Research Institution | University of Miyazaki |
|---|
Principal Investigator |
YAMAGUCHI Hideki University of Miyazaki, 医学部, 講師 (10305097)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOSHINAI Koji 宮崎大学, 医学部, 講師 (80381101)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 生理活性ペプチド / 摂食調節 / エネルギー代謝調節 |
|---|
| Research Abstract |
We have identified two novel carboxy-terminally amidated peptides, Neuroendocrine regulatory peptide (NERP)-1 and NERP-2. Icv administration of NERP-2 increased food intake in rats. NERP-2 expression localized to the lateral hypothalamus, colocalizing with orexins that activate feeding behavior and arousal. Icv administration of NERP-2 also increased body temperature, oxygen consumption, and locomotor activity in rats. Bioactivities of NERP-2 were abrogated by blunting orexin signaling pathway. NERP-2 plays a role in the control of food intake and energy homeostasis via the orexin pathway.
|
-
-
[Journal Article] Distribution of neuroendocrine regulatory peptide-1 and -2, and proteolytic processing of their precursor VGF protein in the rat.2010
Author(s)
Mishiro-Sato E, Sasaki K, Matsuo T, Kageyama H, Yamaguchi H, Date Y, Matsubara M, Ishizu T, Yoshizawa-Kumagaye K, Satomi Y, Takao T, Shioda S, Nakazato M, Minamino N.
-
Journal Title
J Neurochem. 114
Pages: 1097-1106
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
