Therapeutic target for aging osteoporosis～New anti-osteoporosis drug with stimulating bone formation～

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591105
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: OKADA Youske University of Occupational and Environmental Health, Japan, 医学部, 講師 (80333243)
• Co-Investigator(Kenkyū-buntansha): TANAKA Yoshiya 産業医科大学, 医学部, 教授 (30248562)
• Project Period (FY): 2008 – 2010
• Keywords: 内分泌学

Research Abstract

Galectin-9 is a ・-galactoside-binding lectin expressed in various tissues, including bone. The role of galectin-9 in human osteoblasts, however, remains unclear. We showed that galectin-9 interacts with lipid rafts and induces osteoblast proliferation through the c-Src/ERK signaling pathway.

Research Products

• [Journal Article] Galectin-9 induces osteoblast differentiation through the CD44/Smad signaling pathway. (2010)
  • Author(s): Tanikawa R, Tanikawa T, Hirashima M, Yamauchi A, Tanaka Y
  • Journal Title: Biochem Biophys Res Commun 394 Pages: 317-322
  • Peer Reviewed
• [Journal Article] Advanced glycation end products increase endothelial permeability through RAGE/Rho signaling pathway. (2010)
  • Author(s): Hirose A, Tanikawa T, Mori H, Okada Y, Tanaka Y
  • Journal Title: FEBS Letters 584 Pages: 61-66
  • Peer Reviewed
• [Journal Article] Advanced glycation end products induce calcification of vascular smooth muscle cells through RAGE/p38 MAPK. (2009)
  • Author(s): Tanikawa T, Okada Y, Tanikawa R, Tanaka Y
  • Journal Title: J Vascular Res 46 Pages: 572-580
  • Peer Reviewed
• [Journal Article] Alendronate protects premenopausal women from bone loss and fracture associated with high-dose glucocorticoid therapy. (2008)
  • Author(s): Okada Y, Nawata M, Nakayamada S, Saito K, Tanaka Y
  • Journal Title: J Rheumatol 35 Pages: 2249-2254
  • Peer Reviewed
• [Journal Article] Reduced progression to type 2 diabetes from impaired glucose tolerance after a 2-day in-hospital diabetes educational program : the Joetsu Diabetes Prevention Trial. (2008)
  • Author(s): Kawahara T, Takahashi K, Inazu T, Arao T, Kawahara C, Tabata T, Moriyama H, Okada Y, Morita E, Tanaka Y
  • Journal Title: Diabetes Care 31 Pages: 1949-1954
  • Peer Reviewed
• [Journal Article] Induction of hyperadiponectinemia following long-term treatment of patients with rheumatoid arthritis with infliximab (IFX), an anti-TNF-alpha antibody. (2008)
  • Author(s): Nishida K, Okada Y, Nawata M, Saito K, Tanaka Y
  • Journal Title: Endocrine J 20 Pages: 213-216
  • Peer Reviewed
• [Journal Article] Increased esophageal mucosal/submucosal blood flow in patients with gastroesophageal reflux disease : Normalization by treatment with a proton pump inhibitor. (2008)
  • Author(s): Mine S, Iida T, Tabata T, Okada Y, Tanaka Y
  • Journal Title: J Gastroenterol Hepatol 23 Pages: 303-309
  • Peer Reviewed
• [Journal Article] Interaction of galectin-9 with lipid rafts induces osteoblast proliferation through the c-Src/ERK signaling pathway. (2008)
  • Author(s): Tanikawa R, Tanikawa T, Okada Y, Nakano K, Hirashima M, Yamauchi A, Hosokawa R, Tanaka Y
  • Journal Title: J Bone Miner Res 23 Pages: 278-286
  • Peer Reviewed
• [Journal Article] Human mesenchymal stem cells inhibit osteoclastogenesis through osteoprotegerin production.
  • Author(s): Oshita K, Yamaoka K, Udagawa N, Fukuyo S, Sonomoto K, Maeshima K, Kurihara R, Nakano K, Saito K, Okada Y, Chiba K, Tanaka Y
  • Journal Title: Arthritis Rheum (in press)
  • Peer Reviewed
• [Journal Article] Marked improvement of calcinosis in adult dermatomyositis with etidronate therapy.
  • Author(s): Mori H, Okada Y, Yamaoka K, Saito K, Tanaka Y
  • Journal Title: J Bone Miner Metab (in press)
  • Peer Reviewed
• [Presentation] ステロイド骨粗鬆症の早期診断の確立と早期薬剤介入による治療意義 (2010)
  • Author(s): 岡田洋右、他
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-07-21
• [Presentation] ステロイド骨粗鬆症の病態と治療戦略～骨折予防を目指して～ (2010)
  • Author(s): 岡田洋右、田中良哉
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-07-21
• [Presentation] Osteoprotegerin産生を介したヒト間葉系細胞の破骨細胞分化抑制作用 (2010)
  • Author(s): 尾下浩一、岡田洋右、他
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-07-21
• [Presentation] Etidronate Prevents Vascular Calcification and Improves Bone Mineral Density in Patients with Chronic Dialysis. (2010)
  • Author(s): Okada Y, et al.
  • Organizer: 国際内分学会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-29
• [Presentation] Effects of raloxifene on bone metabolism and lipid profile in postmenopausal women with type 2 diabetes mellitus. (2010)
  • Author(s): Mori H, Okada Y, et al.
  • Organizer: 国際内分学会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-29
• [Presentation] 選択的エストロゲン受容体モジュレーターは閉経後2型糖尿病患者における脂質・骨質改善作用を有する (2009)
  • Author(s): 森博子、岡田洋右、他
  • Organizer: 日本骨粗鬆症学会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-21
• [Presentation] アレンドロネートは大量ステロイド療法による骨量減少・骨折を抑止できる (2009)
  • Author(s): 岡田洋右、他
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-23
• [Presentation] Galectin-9はmesenchymal cellの脂肪分化を抑制し骨分化を促進する (2009)
  • Author(s): 谷川隆久、岡田洋右、他
  • Organizer: 日本内分泌学会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-26
• [Presentation] Advanced glycation endproducts (AGE)による血管平滑筋細胞石灰化促進機構の解明 (2008)
  • Author(s): 谷川隆久、岡田洋右、他
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2008-10-29
• [Presentation] ステロイド骨粗鬆症の病態と治療戦略 (2008)
  • Author(s): 岡田洋右、他
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2008-10-29
• [Book] ステロイド性骨粗鬆症と関節リウマチに伴う骨粗鬆症 (2008)
  • Author(s): 岡田洋右、他
  • Total Pages: 87-95
  • Publisher: 医薬ジャーナル社