Functional analysis of BMP-3b as a novel adipocytokine

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591107
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: HINO Jun National Cardiovascular Center Research Institute, 生化学部, 室長 (40260351)
• Co-Investigator(Kenkyū-buntansha): MIYAZATO Mikiya 独立行政法人立循環器病研究センター, 生化学部, 部長 (50291183) ; ARAI Yuji 独立行政法人立循環器病研究センター, 分子生物学部, 室長 (30202724)
• Co-Investigator(Renkei-kenkyūsha): KANGAWA Kenji 独立行政法人国立循環器病研究センター, 研究所長 (00112417)
• Project Period (FY): 2008 – 2010
• Keywords: BMP-3b / アディポサイトカイン / 肥満 / 脂肪細胞 / TGF-β / 分化因子 / 分子型 / 複合体

Research Abstract

We originally isolated BMP-3b,which inhibited osteogenesis, from bone tissue. BMP-3b is strongly expressed not only in the bone but also in adipose tissue. However, the function of BMP-3b in adipose tissue is still unknown. Recent studies show that adipocytokine, which exists in adipose tissue, is involved in metabolic syndrome or its related diseases. We performed functional analysis of BMP-3b in adipose tissue, which demonstrated that BMP-3b acts as a novel adipocytokine that inhibits adipogenesis and its secreted molecular form is a unique complex.

Research Products

• [Journal Article] Bone morphogenetic protein-3b (BMP-3b) is expressed in adipocytes and inhibits adipogenesis as a unique complex. (2011)
  • Author(s): Hino J, Miyazawa T, Miyazato M, Kangawa K.
  • Journal Title: Int.J.Obesity doi.10.1038/ijo(in press) Pages: 124
  • Peer Reviewed
• [Journal Article] Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart. (2008)
  • Author(s): Tokudome T, Kishimoto I, Horio T, Arai Y, Schwenke DO, Hino J, Okano I, Kawano Y, Kohno M, Miyazato M, Nakao K, Kangawa K.
  • Journal Title: Circulation 117 Pages: 2329-39
  • Peer Reviewed
• [Presentation] BMP-3b過剰発現マウスを用いた脂肪組織における機能解析 (2010)
  • Author(s): 日野純
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] BMP-3b functions as a novel adipocytokine that inhibits adipocyte differentiation by its unique complex (2010)
  • Author(s): 日野純
  • Organizer: 8^<th> International Conference on BMPs
  • Place of Presentation: Leuven
  • Year and Date: 2010-09-17
• [Presentation] Bone morphogenetic protein-3b (BMP-3b) is an adipocytokine secreted from preadipocytes and inhibits their differentiation (2010)
  • Author(s): 日野純
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: 京都
  • Year and Date: 2010-03-27
• [Presentation] BMP-3bは脂肪細胞分化抑制作用を有する新たなアディポサイトカインである (2009)
  • Author(s): 日野純
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] BMP-3bの脂肪細胞分化における遺伝子発現およびその新しい分泌型分子型の同定 (2008)
  • Author(s): 日野純
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Remarks] ホームページ等
  • URL: http://www.ncvc.go.jp/res/seika/seikaj_01.html