• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2010 Fiscal Year Final Research Report

The role of megakaryocytic lineage cells in leukemia/lymphoma cell proliferation

Research Project

  • PDF
Project/Area Number 20591113
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionThe University of Tokyo

Principal Investigator

HATTORI Koichi  The University of Tokyo, 医科学研究所, 特任准教授 (10360116)

Project Period (FY) 2008 – 2010
Keywords癌 / 酵素 / 細胞・組織 / 生体分子 / 凝固・線溶
Research Abstract

The main fibrinolytic enzyme, plasmin, can activate matrix metalloproteinases (MMPs) which has been linked to various malignancies. Here we provide the evidence that blockade of Plg reduces leukemia-lymphoma growth by inhibiting MMP activity. The data presented in this study demonstrate a previously undescribed role of plasmin in lymphoproliferative disorders and provide strong evidence that specific blockade of Plg represents a promising approach for the regulation of leukemia-lymphoma growth.

  • Research Products

    (39 results)

All 2011 2010 2009 2008 Other

All Journal Article (10 results) (of which Peer Reviewed: 6 results) Presentation (28 results) Remarks (1 results)

  • [Journal Article] Tumor necrosis receptor-associated factor (Traf)2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease,2011

    • Author(s)
      Piao JH, Hasegawa M, Heissig B, Hattori K, Takeda K, Iwakura Y, Okumura K, Inohara N, Nakano H
    • Journal Title

      J Biol Chem (in press)

    • Peer Reviewed
  • [Journal Article] 血液線維素溶解系因子による骨髄細胞の動態制御 中外医学社Annual Review2011

    • Author(s)
      服部浩一、西田知恵美
    • Journal Title

      血液

      Pages: 187-195

  • [Journal Article] Tissue type plasminogen activator regulates myeloid-cell2010

    • Author(s)
      Ohki M, Ohki Y, Ishihara M, Rosenkvist J, Gritli I, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Nitta A, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Nakauchi H, Werb Z, Heissig B, Hattori K
    • Journal Title

      dependent neoangiogenesis during tissue regeneration Blood 115

      Pages: 4302-4312

    • Peer Reviewed
  • [Journal Article] Role of Neutrophil-derived matrix metalloproteinase-9 for tissue regeneration.2010

    • Author(s)
      Heissig B, Nishida C, Tashiro Y, Sato Y, Ishihara M, Ohki M, Hattori K
    • Journal Title

      Histology & Histopathology 25

      Pages: 765-770

    • Peer Reviewed
  • [Journal Article] Adipocyte-Derived Microvesicles Are Associated with Multiple Angiogenic Factors and Induce Angiogenesis in Vivo and inVitro.2010

    • Author(s)
      Aoki N., Yokoyama R., Asai N., Ohki M., Ohki Y., Kusubata K., Heissig B., Hattori K., Nakagawa Y., Matsuda T.
    • Journal Title

      Endocrinology 151

      Pages: 2567-2576

    • Peer Reviewed
  • [Journal Article] 骨髄異形成と造血微小環境の異常 Dysfuction of bone marrow microenvironment in myelodysplasia2010

    • Author(s)
      服部浩一、佐藤亜紀
    • Journal Title

      血液・腫瘍科 科学評論社 61

      Pages: 660-666

  • [Journal Article] 線維素溶解系による造血幹細胞ニッチの制御機構2010

    • Author(s)
      服部浩一,西田知恵美
    • Journal Title

      日本血栓止血学会雑誌 21

      Pages: 27-31

  • [Journal Article] 造血幹細胞ニッチにおけるMMP-9の役割2010

    • Author(s)
      服部浩一、田代良彦
    • Journal Title

      生化学 第82巻第10号

      Pages: 979-984

  • [Journal Article] Targeted deletion of matrix metalloproteinase-9 reduces neutrophil accumulation during G-CSF-induced neoangiogenesis.2009

    • Author(s)
      Sato Y, Ohki Y, Akiyama H, Rosenkvist J, Gritli I, Okumura K, Ogawa H, Heissig B, Hattori K, Ohsaka A
    • Journal Title

      ytometry Res 19

      Pages: 53-62

    • Peer Reviewed
  • [Journal Article] Metalloproteinase regulation improves in vitro generation of efficacious platelets from embryonic stem cells.2008

    • Author(s)
      Nishikii H, Eto K, Tamura N, Hattori K, Heissig B, Kanaji T, Sawaguchi A, Goto S, Ware J, Nakauchi H
    • Journal Title

      J Exp Med 205

      Pages: 1917-1927

    • Peer Reviewed
  • [Presentation] 生体内細胞分化制御因子としてのMT1-MMPの機能解析2011

    • Author(s)
      西田知恵美、楠畑かおり、田代良彦、清木元治,中内啓光、Heissig Beate、服部浩一
    • Organizer
      第10回日本再生医療学会
    • Place of Presentation
      京王プラザホテル.東京
    • Year and Date
      20110301-20110302
  • [Presentation] 線維素溶解系の活性化による骨髄内間葉系幹細胞の増殖2011

    • Author(s)
      楠畑かおり、小泉摩希子、HeissigBeate、服部浩一
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      京王プラザホテル.東京
    • Year and Date
      20110301-20110302
  • [Presentation] 線溶系因子プラスミンによる赤血球造血制御機構の解明2011

    • Author(s)
      Yurai Okaji, Chiemi Nishida, Koichi Hattori, Beate Heissig
    • Organizer
      ワークショップ「個体レベルのがん研究の魅力:培養細胞と臨床研究をつなぐマトリクス」
    • Place of Presentation
      琵琶湖ホテル.大津
    • Year and Date
      20110203-20110204
  • [Presentation] MT1-MMP plays a critical role in the cell growth and maturation.2011

    • Author(s)
      Chiemi Nishida, Kaori Kusubata, Motoharu Seiki, Hiromitsu Nakauchi, Koichi Hattori, Beate Heissig
    • Organizer
      ワークショップ「個体レベルのがん研究の魅力:培養細胞と臨床研究をつなぐマトリクス」
    • Place of Presentation
      琵琶湖ホテル.大津
    • Year and Date
      20110203-20110204
  • [Presentation] KoichiHattori MT1-MMP Plays a Critical Role In the Modulation of Hematopoiesis2010

    • Author(s)
      Nishida Chiemi, Heissig Beate, Tashiro Yoshihiko, Seiki Motoharu, Hiromithu Nakauchi
    • Organizer
      52nd ASH Annual Meeting ; Orange County Convention Center
    • Place of Presentation
      Orlando, FL
    • Year and Date
      20101204-20101207
  • [Presentation] Plasminogen Deficiency Impairs Erythropoietic Recovery Capacity in Male C57BL/6J Mice through Testosterone Defect.2010

    • Author(s)
      Okaji Yurai, Nishida Chiemi, Gritli Ismael, Tashiro Yoshihiko, Ohki Makiko, Hattori Koichi, Heissig Beate
    • Organizer
      52nd ASH Annual Meeting ; Orange County Convention Center
    • Place of Presentation
      Orlando, FL
    • Year and Date
      20101204-20101207
  • [Presentation] 服部浩一 MT1-MMP is a critical modulator of normal hematopoiesis.2010

    • Author(s)
      Chiemi Nishida, Heissig, Motoharu Seiki, Hiromitsu Nakauchi
    • Organizer
      第72回日本血液学会
    • Place of Presentation
      パシフィコ横浜.横浜
    • Year and Date
      20100924-20100926
  • [Presentation] リンパ腫増殖における線維素溶解系の役割と新規治療法の開発2010

    • Author(s)
      石原誠人、ベアテハイジッヒ、田代良彦、西田知恵美、小泉摩希子、和中敬子、津田裕子、岡田芳男、八木田秀雄、奥村康、中内啓光、服部浩一
    • Organizer
      第72回日本血液学会
    • Place of Presentation
      パシフィコ横浜.横浜
    • Year and Date
      20100924-20100926
  • [Presentation] 生体内組織再生における線溶系因子PAI-1の機能解明2010

    • Author(s)
      田代良彦、石原誠人、西田知恵美、Ismail Gritli1)、小泉摩季子、小見山博光、坂本一博、Beate Heissig、宮田敏男、中内啓光、服部浩一
    • Organizer
      第72回 日本血液学会
    • Place of Presentation
      パシフィコ横浜.横浜
    • Year and Date
      20100924-20100926
  • [Presentation] Epidermal growth factor-like domain 7, a vascular niche factor, regulates myelopoiesis.2010

    • Author(s)
      Ismael Gritli, Chiemi Nishida, Makoto Ishihara, Hiromitsu Nakauchi, Koichi Hattori, Beate Heissig.
    • Organizer
      The 72nd Annual Meeting of the Japanese Society of Hematology.
    • Place of Presentation
      Pacifico Yokohama
    • Year and Date
      2010-09-24
  • [Presentation] 癌増殖における線維素溶解系因子の役割と新規治療法の開発2010

    • Author(s)
      石原誠人、山本玲、八木田秀雄、奥村康、ハイジッヒベアテ、服部浩一
    • Organizer
      第69回日本癌学会学術集会
    • Place of Presentation
      大阪国際会議場.大阪
    • Year and Date
      2010-09-24
  • [Presentation] 癌間質・微小環境形成における骨髄由来細胞動員の意義2010

    • Author(s)
      服部浩一
    • Organizer
      第51回日本臨床細胞学会指名講演
    • Place of Presentation
      パシフィコ横浜 横浜
    • Year and Date
      2010-05-31
  • [Presentation] Contribution of the fibrinolytic system to hematopoiesis and angiogenesis during tissue regeneration.2010

    • Author(s)
      服部浩一
    • Organizer
      第33回日本血栓止血学会学術集会招待講演
    • Place of Presentation
      城山観光ホテル.鹿児島
    • Year and Date
      2010-04-20
  • [Presentation] プロテアーゼ活性化を起点とした癌と骨髄とのクロストーク.2009

    • Author(s)
      服部浩一
    • Organizer
      第12回癌と骨病変研究会招待講演
    • Place of Presentation
      大阪・千里
    • Year and Date
      2009-11-20
  • [Presentation] The Role of fibrinolytic system in lymphoma progression ; implication for targets.2009

    • Author(s)
      Ishihara M, Heissig B, Tashiro Y, Tsuda Y, Wanaka K, Okada Y, Hattori K
    • Organizer
      The 71^<st> Annual Meeting of the Japanese Society of Hematology 2009 : Kyoto(第71回日本血液学会総会ワークショップ発表)
    • Place of Presentation
      京都
    • Year and Date
      2009-10-23
  • [Presentation] tPA regulates bone marrow derived cell dependent neoangiogenesis during tissue regeneration.2009

    • Author(s)
      Hattori K, Ohki M, Ohki Y, Nishida C, Ishihara M, Tashiro Y, Gritli I, Nakauchi H, Heissig B
    • Organizer
      The 71^<st> Annual Meeting of the Japanese Society of Hematology(第71回日本血液学会総会プレナリーセッション発表)
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-10-23
  • [Presentation] 生体内造血制御機構におけるMT1-MMPの機能解析2009

    • Author(s)
      西田知恵美,Heissig Beate,清木元治,中内啓光,服部浩一
    • Organizer
      第71回日本血液学会総会発表
    • Place of Presentation
      京都
    • Year and Date
      2009-10-23
  • [Presentation] 癌微小環境形成における骨髄由来細胞の動員機構2009

    • Author(s)
      服部浩一,石原誠人,Heissig B
    • Organizer
      第10回運動器科学研究会招待講演
    • Place of Presentation
      東京
    • Year and Date
      2009-09-18
  • [Presentation] Fibrinolytic system plays a key role in tumor growth and apoptosis.2009

    • Author(s)
      Resenkvist J, Ishihara M, Ismael Gritli, Nishida C, Heissig Beate、Hattori K
    • Organizer
      平成21年度医科学研究所研究成果発表会
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-06-01
  • [Presentation] 生体内造血制御機構におけるMT1-MMPの重要性2009

    • Author(s)
      西田知恵美,新谷大悟,清木元治,Heissig Beate,服部浩一
    • Organizer
      第8回日本再生医療学会総会口演
    • Place of Presentation
      東京
    • Year and Date
      2009-03-05
  • [Presentation] 末梢血幹細胞動員における線溶系因子の機能解析2009

    • Author(s)
      大木摩希子,大木勇一,秋山晴代,Heissig Beate,服部浩一
    • Organizer
      第8回日本再生医療学会総会発表
    • Place of Presentation
      東京
    • Year and Date
      2009-03-05
  • [Presentation] 血液線維素溶解系と骨髄細胞動態との相関2008

    • Author(s)
      服部浩一
    • Organizer
      第14回血液科学セミナー招待講演
    • Place of Presentation
      東京
    • Year and Date
      20080000
  • [Presentation] 骨髄由来細胞動員を介した組織再生制御機構2008

    • Author(s)
      服部浩一
    • Organizer
      第59回日本電気泳動学会シンポジウム指名講演
    • Place of Presentation
      神奈川
    • Year and Date
      2008-11-15
  • [Presentation] 骨髄由来細胞によるがん関連ニッチ形成機構2008

    • Author(s)
      服部浩一
    • Organizer
      第26回日本骨代謝学会学術集会ミニシンポジウム指名講演
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-30
  • [Presentation] 骨髄由来細胞動員による腫瘍血管新生制御機構2008

    • Author(s)
      服部浩一
    • Organizer
      第67回日本癌学会学術総会指名講演
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
  • [Presentation] 生体内造血制御機構におけるMT1-MMPの重要性2008

    • Author(s)
      西田知恵美、新谷大悟、清木元治、Heissig Beate、服部浩一
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
  • [Presentation] 癌増殖における線維素溶解系因子の役割と新規治療法の開発2008

    • Author(s)
      石原誠人、Heissig Beate、服部浩一
    • Organizer
      第70回日本血液学会総会・優秀ポスター賞
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
  • [Presentation] Fibrinolytic system regulates myeloid-cell dependent neoangiogenesis during tissue regeneration.

    • Author(s)
      服部浩一
    • Organizer
      3^<rd> Symposium of IMSUT & RCAST Global COE on New Horizon of Stem Cell Biology and Immunotherapy
    • Place of Presentation
      東京大学医科学研究所 東京都
  • [Remarks] ホームページ等

    • URL

      http://stemcell-u-tokyo.org/sc-re/

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi