2010 Fiscal Year Final Research Report
Analysis of the mechanisms of RUNX1 gene regulation in the pathogenesis of leukemia
Project/Area Number |
20591114
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hematology
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Research Institution | University of Yamanashi |
Principal Investigator |
SAKOE Kumi University of Yamanashi, 医学部, ポストドクター (10398505)
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Co-Investigator(Kenkyū-buntansha) |
KOMATU Norio 順天堂大学, 医学部, 教授 (50186798)
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Co-Investigator(Renkei-kenkyūsha) |
KIRITO Keita 山梨大学, 大学院・医学工学総合研究部, 教授 (90306150)
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Project Period (FY) |
2008 – 2010
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Keywords | RUNX1 / 家族性血小板減少症 / 白血球 / 遺伝子変異 / 発現調節 |
Research Abstract |
RUNX1 is a transcription factor that is essential for hematopoiesis and is the causative gene of the familial platelet disorder that developing leukemia in a high risk. SNP in the promoter region of RUNX1 gene effects on the RUNX1 transcription, and allelic imbalance causes the over-expression of mutation transcript in the same allele at SNP. New 4 lysine residues in the carboxyl terminal of mutant RUNX1 protein that differs from normal RUNX1 due to a frame shift mutation are target of ubiquitination and degradation. It was suggested that the allelic expression imbalance and a decrease of protein level cause the risk of leukemia.
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[Journal Article] Inhibition of HIF-1 function enhances the sensitivity of multiple myeloma cells to melphalan2009
Author(s)
ongzhen Hu, Kirito K, Yoshida K, Mitsumori T, Nakajima K, Nozaki Y, Hamanaka S, Nagashima T, Kunitama M, Sakoe K, Komatsu N.
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Journal Title
Molecular cancer therapeutics 8
Pages: 2329-2338
Peer Reviewed
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