Development of phosphor sugar derivatives for hematological malignancy therapy

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591115
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: NAKAMURA Satoki Hamamatsu University School of Medicine, 医学部附属病院, 助教 (20377740)
• Co-Investigator(Kenkyū-buntansha): ONO Takaaki 浜松医科大学, がん教育センター, 助教 (40402276) ; FUJIE Michio 浜松医科大学, 実験実習機器センター, 技術専門職員 (90397373) ; OHNISHI Kazunori 浜松医科大学, 医学部付属病院, 教授 (80252170)
• Project Period (FY): 2008 – 2010
• Keywords: 癌 / シグナル伝達 / 糖化合物 / 薬理学 / 蛋白質

Research Abstract

We investigated the synthesis, identification of target molecules, and characterization of molecular targeted drugs as a new class of potential panti-proliterative materials for leukemia cells and other cancer cells. We will perform the development of cancer-specific drugs for cancer therapy.

Research Products

• [Journal Article] The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia. (2010)
  • Author(s): Nakamura S, Hirano I, Okinaka K, Takemura T, Yokota D, Ono T, Shigeno K, Shibata K, Fujisawa S, Ohnishi K.
  • Journal Title: Carcinogenesis. 31 Pages: 2012-2021
  • Peer Reviewed
• [Journal Article] Research and development of phospha sugar anti-cancer agents with anti-leukemic activity. (2010)
  • Author(s): Yamashita J, Suyama T, Asai K, Yamada M, Niimi T, Fujie M, Nakamura S, Ohnishi K, Yamashita M.
  • Journal Title: Heterocyclic communications. 2 Pages: 89-98
  • Peer Reviewed
• [Journal Article] Synthesis of some 1-aryl-2, 3-dibromophospholanes as novel anti-cancer agents. (2010)
  • Author(s): Yamada M, Asai K, Yamashita J, Suyama T, Niimi T, Maddali K, Fujie M, Nakamura S, Kimura M, Tanaka Y, Toda M, Yamashita M.
  • Journal Title: Heterocyclic communications. 2 Pages: 165-171
  • Peer Reviewed
• [Journal Article] A novel phospha sugar analogue : synthesis and evaluation of 2, 3-dibromo-3-methyl-1-phenylphospholane 1-oxide as a new class of potential panti-proliterative materials for leukemia cells. (2010)
  • Author(s): Fujie M, Nakamura S, Asai K, Niimi T, Yamashita J, Kiyofuji K, Shibata K, Suzuki M, Aoshima R, Urano T, Yamashita M.
  • Journal Title: Heterocyclic Communications. 30 Pages: 945-950
  • Peer Reviewed
• [Journal Article] Preparation and characterization of novel 4-bromo-3, 4-dimethyl-1-phenyl-2-phospholene 1-oxide and the analogous phosphorus heterocycles or phospha sugars. (2010)
  • Author(s): Yamada M, Yamashita M, Suyama T, Yamashita J, Asai K, Niimi T, Ozaki N, Fujie M, Maddali K, Nakamura S, Ohnishi K.
  • Journal Title: Bioorganic & Medicinal Chemistry Letters. 20(19) Pages: 5943-5946
  • Peer Reviewed
• [Journal Article] Development and pharmacologic characterization of deoxybromophospha sugar derivatives with antileukemic activity. (2010)
  • Author(s): Nakamura S, Yamashita M, Yokota D, Hirano I, Ono T, Fujie M, Shibata K, Niimi T, Suyama T, Maddali K, Asai K, Yamashita J, Iguchi Y, Ohnishi K.
  • Journal Title: Investigational New Drugs 28(4) Pages: 381-391
  • Peer Reviewed
• [Journal Article] A novel phospha sugar analogue : synthesis and evaluation of 2, 3-dibromo-3-methyl-1-phenylphospholane 1-oxide having potential anti-proliferative effects for human tumors. (2009)
  • Author(s): Fujie M, Nakamura S, Asai H, Yamashita J, Kiyofuji K, Yamashita M.
  • Journal Title: Journal of Environmental Biology 30(6) Pages: 945-950
  • Peer Reviewed
• [Journal Article] Preparation and Characterization of Phospholenes and Phospha Sugars as Novel Anti-cancer Agents. (2009)
  • Author(s): Ito S, Yamashita M, Niimi T, Fujie M, Valluru KR, Totsuka H, Buchammagari H, Maddali KR, Nakamura S, Asai K, Suyama T, Yamashita J, Iguchi Y, Gang Y, Oshikawa T.
  • Journal Title: Heterocyclic Communications. 15 Pages: 23-30
  • Peer Reviewed
• [Presentation] Identification of target molecules and anti-leukemic effects of novel phospha sugar derivative, TMPP. (2010)
  • Author(s): 中村悟己
  • Organizer: 101^<th> annual meeting of American Association for Cancer Research.
  • Place of Presentation: Washington DC, USA.
  • Year and Date: 2010-04-19
• [Presentation] 癌(がん)の早期発見・早期治療のための医用材料のイノベーション (2009)
  • Author(s): 山下光司
  • Organizer: イノベーションジャパン2009
  • Place of Presentation: 東京国際会議場、東京
  • Year and Date: 20090916-20090918
• [Presentation] 新規合成リン糖誘導体TMPPの標的分子同定と抗白血病効果の機序の解明 (2009)
  • Author(s): 中村悟己
  • Organizer: 第71回日本血液学会総会
  • Place of Presentation: 国立京都国際会館、京都
  • Year and Date: 2009-10-23
• [Presentation] Development and pharmacologic characterization of deoxybromophospha sugar derivatives with anti-leukemic effects : Inhibition of cell cycle progression through FoxM1 regulation. (2009)
  • Author(s): 中村悟己
  • Organizer: 100^<th> annual meeting of American Association for Cancer Research
  • Place of Presentation: Denver, Colorado, USA.
  • Year and Date: 2009-04-20
• [Remarks] ホームページ等
• [Patent(Industrial Property Rights)] 含リン化合物及び抗腫瘍剤 (2007)
  • Inventor(s): 山下光司、中村悟己、藤江三千男
  • Industrial Property Rights Holder: 国立大学法人静岡大学
  • Industrial Property Number: 特許,特願2007-35083
  • Filing Date: 2007-02-15