2010 Fiscal Year Final Research Report
Analyses of the mechanisms of resistance to monoclonal antibody therapy and exploration of overcoming strategies.
| Project/Area Number |
20591116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Nagoya University |
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Principal Investigator |
TOMITA Akihiro Nagoya University, 医学部附属病院, 講師 (80378215)
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| Co-Investigator(Renkei-kenkyūsha) |
KIYOI Hitoshi 名古屋大学, 医学部附属病院, 講師 (90314004)
AOKI Ichio 独立行政法人放射線医学研究所, 分子イメージング研究センター, チームリーダー (10319519)
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| Project Period (FY) |
2008 – 2010
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| Keywords | CD20 / リツキシマブ / 抗体療法 / 分子標的治療 / エピジェネティクス / 薬剤耐性 / 分子イメージング |
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| Research Abstract |
We focused on the phenomenon CD20-negative phenotypic change after performing chemotherapies with rituximab in CD20-positive B-cell lymphoma cells, and the molecular mechanisms of CD20-negative change were analyzed. It appears that aberrant down-regulation of MS4A1 gene expression is closely related to CD20-negative phenotype, and the repression may be introduced by recruitment of Sin3-HDAC1 protein complex to MS4A1 promoter region. CD20-negative phenotype is related to resistance to rituximab therapy. Down-regulated CD20 expression can be partially stimulated by epigenetic drugs resulting in partial restoration of rituximab sensitivity.
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Research Products
(40 results)
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[Journal Article] Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome.2008
Author(s)
Xu J, Suzuki M, Niwa Y, Hiraga J, Nagasaka T, Ito M, Nakamura S, Tomita A, Abe A, Kiyoi H, Kinoshita T, Naoe T
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Journal Title
Br J Haematol. 140(4)
Pages: 394-401
Peer Reviewed
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[Presentation] CD20-Negative Phenotypic Change In B-Cell Lymphoma Cells After Using Rituximab: Possibility of a Particular Clinicopathologic Phenomenon Post- Rituximab Extranodal CD20-Negative Lymphoma2010
Author(s)
冨田章裕, 徳永隆之, 入山智沙子, 島田和之, 平賀潤二, 杉本匠, 清井仁, 中村栄男, 木下朝博士, 直江知樹
Organizer
The American Society of Hematology, 52th Annual Meeting
Place of Presentation
Orlando, FL, USA
Year and Date
2010-12-05
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