2010 Fiscal Year Final Research Report
Growth and differentiation of hematopoietic tumor cells through transcriptional Mediator complex
| Project/Area Number |
20591125
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kobe University |
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Principal Investigator |
ITO Mitsuhiro Kobe University, 大学院・保健学研究科, 教授 (50362794)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 血液内科学 / 転写メディエーター / MED1 / TRAP220 |
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| Research Abstract |
The transcriptional Mediator complex, subcomplex of the RNA polymerase II holoenzyme complex, ultimately integrates many intracellular signals and conveys these signals to the RNA polymerase II core enzyme complex. In this study, we have shown that the Mediator subunit MED1 plays an important role in malignant, as well as normal, hematopoietic cell differentiation as a specific coactivator for nuclear receptors and GATA1, key activators for hematopoiesis. MED1 appears to promote proliferation of these cells as well. We also propose the molecular mechanisms underlying these processes.
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[Journal Article] Transcriptional Mediator subunit MED1/TRAP220 in stromal cells is involved in hematopoietic stem/progenitor cell support through osteopontin expression.2010
Author(s)
A.Sumitomo, R.Ishino, N.Urahama, K.Inoue, K.Yonezawa, N.Hasegawa, O.Horie, H.Matsuoka, T.Kondo, R.G.Roeder, M.Ito
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Journal Title
Mol.Cell.Biol. 30
Pages: 4818-4827
Peer Reviewed
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[Journal Article] Association between the neutrophil myeloperoxidase index (MPXI) and subsets of bacterial infections.2010
Author(s)
K.Yonezawa, O.Horie, A.Yoshioka, S.Matsuki, T.Tenjin, Y.Tsukamura, M.Yoneda, K.Shibata, Y.Koike, T.Nomura, M.Yokoyama, N.Urahama, M.Ito
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Journal Title
Int.J.Lab.Hematol. 32
Pages: 598-605
Peer Reviewed
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[Presentation] Mediator subunit MED1/TRAP220 in stromal cells is involved in hematopoietic stem/progenitor cell support through osteopontin expression.2010
Author(s)
A.Sumitomo, R.Ishino, N.Urahama, K.Inoue, K.Yonezawa, N.Hasegawa, O.Horie, H.Matsuoka, T.Kondo, R.G.Roeder, M.Ito
Organizer
第33回日本分子生物学会年会第83回日本生化学会大会合同大会
Place of Presentation
神戸
Year and Date
20101207-20101210
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[Presentation] Association between the neutrophil myeloperoxidase index (MPXI) and subsets of bacterial infections.2010
Author(s)
K.Yonezawa, O.Horie, A.Yoshioka, S.Matsuki, T.Tenjin, Y.Tsukamura, M.Yoneda, K.Shibata, Y.Koike, T.Nomura, M.Yokoyama, N.Urahama, M.Ito
Organizer
23rd International Symposium on Technological Innovations in Laboratory Hematology
Place of Presentation
Brighton, U.K.
Year and Date
20100510-20100512
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[Presentation] Transcriptional Mediator subunit MED1/TRAP220 acts in stromal cells to support hematopoietic stem/progenitor cells through coactivation of osteopontin transcription.2009
Author(s)
A.Sumitomo, N.Urahama, K.Inoue, R.Ishino, K.Yonezawa, N.Hasegawa, C.Iwasaki, O.Horie, N.Seki, M.Ito
Organizer
51st Annual Meeting of the American Society of Hematology
Place of Presentation
New Orleans, L.A., USA.(口演)
Year and Date
20091204-20091207
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[Presentation] Association of neutrophil myeloperoxidase index (MPXI) with subsets of bacterial infection.2009
Author(s)
K.Yonezawa, O.Horie, A.Yoshioka, S.Matsuki, T.Tenjin, Y.Tsukamura, M.Yoneda, K.Shibata, Y.Koike, T.Nomura, Y.Yokoyama, M.Ito
Organizer
European Hematology Association 14th Annual Congress.
Year and Date
2009-06-07
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