2010 Fiscal Year Final Research Report
Functional analysis of miRNA/transcription factors highly expressed in leukemia stem cells
| Project/Area Number |
20591134
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kyushu University |
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Principal Investigator |
TAKENAKA Katsuto Kyushu University, 大学病院, 助教 (30301295)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 白血病幹細胞 |
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| Research Abstract |
Normal hematopoiesis and acute myeloid leukemia are organized as hierarchies with stem cells, which possess extensive self-renewal and proliferative capacity. We identified a core transcriptional program shared by normal and leukemia stem cells, revealing the molecular machinery underlying stemness properties. Biological derteminants of stemness influence clinical outcome of leukemia, and are potential targets for novel therapy.
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