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2010 Fiscal Year Final Research Report

Basic research on new therapy for leukemia by a decoy peptide.

Research Project

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Project/Area Number 20591140
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionDokkyo Medical University

Principal Investigator

MAKI Kazuhiro  Dokkyo Medical University, 医学部, 講師 (50337391)

Co-Investigator(Kenkyū-buntansha) MITANI Kinuko  獨協医科大学, 医学部, 教授 (50251244)
SASAKI Ko  獨協医科大学, 医学部, 講師 (60282638)
Project Period (FY) 2008 – 2010
Keywords白血病 / RUNX1 / EVI1 / ヒストン脱アセチル化酵素阻害剤
Research Abstract

RUNX1/EVI1 is a chimeric gene that is observed in advanced-stage MDS and blastic crisis of chronic myelogenous leukemia. RUNX1/EVI1 enhances colony-forming and self-renewal abilities of mouse bone marrow progenitors. We have shown that Histone deacetylase inhibitors exhibit specific repression on these phenotypes.

  • Research Products

    (2 results)

All 2010 2008

All Presentation (2 results)

  • [Presentation] Molecular pathogenesis of MDS and its clinical implications2010

    • Author(s)
      牧和宏、三谷絹子
    • Organizer
      第72回日本血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-26
  • [Presentation] ヒストン脱アセチル化酵素阻害薬を用いたRUNX1/EVI1の造腫瘍活性の抑制2008

    • Author(s)
      牧和宏、山形哲也、佐々木光、三谷絹子
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12

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Published: 2012-01-26   Modified: 2016-04-21  

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