Elucidation of molecular pathogenesis and control of thrombosis in metabolic syndrome

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591148
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Nagoya University
• Principal Investigator: YAMAMOTO Koji Nagoya University, 医学部附属病院, 講師 (90362251)
• Co-Investigator(Kenkyū-buntansha): KOJIMA Tetsuhito 名古屋大学, 医学部, 教授 (40161913)
• Project Period (FY): 2008 – 2010
• Keywords: 血栓症 / 高血圧 / 肥満 / 糖尿病 / ストレス / 脂肪細胞 / サイトカイン / 線溶

Research Abstract

Dramatic induction both of PAI-1, a principal regulator of fibrinolytic system, and TF, an initiator of coagulation, was observed in obese mouse, especially in their adipose tissues, which consist of large adipocytes. When obese mice encounter mental stress, they produce more amounts of PAI-1 and TF. These observations suggest that prothrombotic state progresses in metabolic syndrome, especially in stressful conditions.

Research Products

• [Journal Article] Donor screening algorithm for exclusion of thrombophilia during evaluation of living donor liver transplantation. (2011)
  • Author(s): Ogawa H, Fujimoto Y, Yamamoto K, Hata T, Nagai S, Kamei H, Arikawa T, Nakamura T, Kiuchi T.
  • Journal Title: Clinical Transplantation 印刷中
  • Peer Reviewed
• [Journal Article] Pitavastatin-induced angiogenesis and arteriogenesis is mediated by Notch1 in a murine hindlimb ischemia model without induction of VEGF (2011)
  • Author(s): Kikuchi R, Takeshita K, Kondo M, Uchida Y, Cheng XW, Nakayama T, Yamamoto K, Matsushita T, Liao J, Murohara T
  • Journal Title: Laboratory Investigation 印刷中
  • Peer Reviewed
• [Journal Article] A novel splice site mutation in intron C of PROS1 leads to markedly reduced mutant mRNA level, absence of thrombin-sensitive region, and impaired secretion and cofactor activity of mutant protein S. (2010)
  • Author(s): Okada H, Kunishima S, Hamaguchi M, Takagi A, Yamamoto K, Takamatsu J, Matsushita T, Saito H, Kojima T, Yamazaki T.
  • Journal Title: Thrombosis Research 125 Pages: e246-e250
  • Peer Reviewed
• [Journal Article] Adipose tissue-derived mesenchymal stem cells facilitate hematopoiesis in vitro and in vivo : advantages over bone marrow-derived mesenchymal stem cells. (2010)
  • Author(s): Nakao N, Nakayama T, Yahata T, Muguruma Y, Saito S, Miyata Y, Yamamoto K, Naoe T.
  • Journal Title: American Journal of Pathology 177 Pages: 547-554
  • Peer Reviewed
• [Journal Article] Severe hemophilia A in a Japanese female caused by an F8-intron 22 inversion associated with skewed X chromosome inactivation. (2010)
  • Author(s): Miyawaki Y, Suzuki A, Fujimori Y, Takagi A, Murate T, Suzuki N, Katsumi A, Naoe T, Yamamoto K, Matsushita T, Takamatsu J, Kojima T.
  • Journal Title: International Journal of Hematology 92 Pages: 405-408
  • Peer Reviewed
• [Journal Article] PAI-1の臨床的意義 (2010)
  • Author(s): 山本晃士
  • Journal Title: 日本医事新報 4488 Pages: 81-83
• [Journal Article] メタボリックシンドロームと血栓症 (2010)
  • Author(s): 山本晃士
  • Journal Title: 最新医学「血栓症」 65 Pages: 1130-1136
• [Remarks] ホームページ等