2010 Fiscal Year Final Research Report
Analysis of inhibitory mechanism and antithrombotic effects of a novel anti-platelet function molecule, semaphorin 3A
| Project/Area Number |
20591151
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka University |
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Principal Investigator |
KASHIWAGI Hirokazu Osaka University, 医学系研究科, 助教 (10432535)
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| Co-Investigator(Kenkyū-buntansha) |
TOMIYAMA Yoshiaki 大阪大学, 医学部附属病院, 講師 (80252667)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 血小板 / セマフォリン / シグナル伝達 / 血栓 / 動脈硬化 |
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| Research Abstract |
We analyzed the mechanism of inhibition of platelet function by semaphorin 3A. In addition to inhibition of actin polymerization via suppression of Rac-paxillin pathway, we found that semaphorin 3A inhibits downstream molecules of PI3 kinase, Rap1 and AKT. Interestingly, semaphorin 3A inhibited both thrombin-or convulxin-induced Rap1 and AKT activation, it inhibited mainly ADP-induced AKT phosphorylation. These results indicate that semaphorin 3A inhibits PI3 kinase pathway, and it may have direct inhibitory effects on ADP-induced AKT activation.
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