2010 Fiscal Year Final Research Report
Activation of platelet toll-like receptors and its clinical significance
| Project/Area Number |
20591153
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Ehime University |
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Principal Investigator |
HATO Takaaki Ehime University, 医学部附属病院, 准教授 (30172943)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMANOUCHI Jun 愛媛大学, 医学部附属病院, 講師 (10423451)
YASUKAWA Masaki 愛媛大学, 医学系研究科, 教授 (60127917)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 血小板 / TOLL-like receptor / 自然免疫 / 細菌感染症 |
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| Research Abstract |
We examined the role of toll-like receptors (TLR) on the platelet surface. Stimulation of platelet TLR with bacterial components promoted the platelet adhesive response through another platelet receptor. Serum from patients with sepsis, a severe bacterial infection, promoted the platelet adhesive response through platelet TLR. These results indicate that the linkage between platelets and various pathogens promotes the platelet adhesive activity, suggesting a crucial role of platelets on the host defense mechanism.
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Research Products
(21 results)
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[Journal Article] Identification of an epitope derived from CML66, a novel tumor-associated antigen expressed broadly in human leukemia, recognized by human leukocyte antigen-A*2402- restricted cytotoxic T lymphocytes.2008
Author(s)
Suemori K, Fujiwara H, Ochi T, Azuma T, Yamanouchi J, Narumi H, Yakushijin Y, Hato T, Hasegawa H, Yasukawa M
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Journal Title
Cancer Sci 99
Pages: 1414-1419
Peer Reviewed
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