2010 Fiscal Year Final Research Report
Combined application of molecular-targeted therapy and NKT immunotherapy for hematological malignancy
| Project/Area Number |
20591160
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SHIMIZU Kanako The Institute of Physical and Chemical Research, 免疫治療モデル開発研究ユニット, ユニットリーダー (20391980)
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| Co-Investigator(Kenkyū-buntansha) |
FUJII Shinーichiro 独立行政法人理化学研究所, 免疫細胞移植戦略研究ユニット, ユニットリーダー (10392094)
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| Project Period (FY) |
2008 – 2010
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| Keywords | NKT細胞 / α-GalCer / 腫瘍細胞 / 自然免疫 / 獲得免疫 |
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| Research Abstract |
We have been focusing on the development of anti-tumor vaccine using adjuvant activity of NKT cells, which is α-Galcer loaded tumor cells (Tumor/Gal). In current study, we evaluated the efficacy of combination of Tumor/Gal with anti-cancer drug or molecular-targeted therapy in hematological tumor models. We found the possibility of synergistic effect of these approaches.
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[Journal Article] A set of genes associated with the interferon-γ response of lung cancer patients undergoing α-galactosylceramide-pulsed dendritic cell therapy.2010
Author(s)
Okita K, Motohashi S, Shinnakasu R, Nagato K, Yamasaki K, Sato Y, Kitamura H, Hijikata A, Yamashita M, Shimizu K, Fujii S, Ohara O, Taniguchi M, Sakaida I, Nakayama T
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Journal Title
Cancer Sci. 101
Pages: 2333-2340
Peer Reviewed
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[Journal Article] Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells.2010
Author(s)
Watarai H, Fujii S, Yamada D, Rybouchkin A, Sakata S, Nagata Y, Iida-Kobayashi M, Sekine-Kondo E, Shimizu K, Shozaki Y, Sharif J, Matsuda M, Mochiduki S, Hasegawa T, Kitahara G, Endo TA, Toyoda T, Ohara O, Harigaya K, Koseki H, Taniguchi M
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Journal Title
J Clin Invest. 120
Pages: 2610-2618
Peer Reviewed
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[Journal Article] Induction of Th1-biased cytokine production by alpha-carba-GalCer, a neoglycolipid ligand for NKT cells.2010
Author(s)
Tashiro T, Sekine-Kondo E, Shigeura T, Nakagawa R, Inoue S, Omori-Miyake M, Chiba T, Hongo N, Fujii S, Shimizu K, Yoshiga Y, Sumida T, Mori K, Watarai H, Taniguchi M
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Journal Title
Int Immunol 22
Pages: 319-328
Peer Reviewed
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[Journal Article] Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Valpha14-Jalpha18 TCRalpha gene.2010
Author(s)
Watarai H, Rybouchkin A, Hongo N, Nagata Y, Sakata S, Sekine E, Dashtsoodol N, Tashiro T, Fujii S, Shimizu K, Mori K, Masuda K, Kawamoto H, Koseki H, Taniguchi M
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Journal Title
Blood. 115
Pages: 230-237
Peer Reviewed
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