2010 Fiscal Year Final Research Report
Sleep disturbance and related changes of circadian rhythm in patients with rheumatoid arthritis.
| Project/Area Number |
20591170
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
膠原病・アレルギー・感染症内科学
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
HASHIRAMOTO Akira Kobe University, 医学研究科, 特命准教授 (80346246)
|
|---|
| Research Collaborator |
TSUMIYAMA Ken 神戸大学, 保健学研究科, 助教
KAWAZOE Takako 神戸大学, 保健学研究科・大学院
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 関節リウマチ / 睡眠 / 概日リズム |
|---|
| Research Abstract |
The sleep of patients with rheumatoid arthritis (RA) was significantly disturbed in relation to their disease activities. 95.0% of patients maintained a fair daytime awakening while 51.0% of them suffered from depressive states. Patients showed a significant increase in wake after sleep onset and a decrease in sleep efficiency. In particular, the ratio of Stage1 non-REM sleep was incresed (p<0.05), and the values correlated significantly with patients' disease activity.
|
Research Products
(72 results)
-
-
-
[Journal Article] Prospective study of methotrexate treatment for rheumatoid arthritis treated legitimately according to the government recommended 8 mg/week dose.2009
Author(s)
Hashiramoto A, Shiozawa K, Tanaka Y, Yamane T, Murata M, Tanaka C, Terashima Y, Koyama K, Nakagawa N, Abe S, Yoshihara R, Saegusa Y, Tsumiyama K, Komai K, Sakai Y, Shiozawa S.
-
Journal Title
Mod Rheumatol.
Pages: 637-642
Peer Reviewed
-
[Journal Article] Sjogren's syndrome patients presenting with hypergammaglobulinemia are relatively unresponsive to cevimeline treatment.2009
Author(s)
Komai K, Shiozawa K, Tanaka Y, Yoshihara R, Tanaka C, Sakai H, Yamane T,Murata M, Tsumiyama K, Hashiramoto A, Shiozawa S.
-
Journal Title
Mod Rheumatol. 19
Pages: 416-419
Peer Reviewed
-
[Journal Article] Low- versus high-baseline epinephrine output shapes opposite innate cytokine profiles : presence of Lewis- and Fischer-like neurohormonal immune phenotypes in humans?2008
Author(s)
Elenkov IJ, Kvetnansky R, Hashiramoto A, Bakalov VK, Link AA, Zachman K, Crane M, Jezova D, Rovensky J, Dimitrov MA, Gold PW, Bonini S, Fleisher T, Chrousos GP, Wilder RL.
-
Journal Title
J Immunol. 181
Pages: 1737-1745
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
