2010 Fiscal Year Final Research Report
Regulation of heme oxygenase-1 expression and the therapeutic application in rheumatic and inflammatory diseases
| Project/Area Number |
20591174
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Yokohama City University |
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Principal Investigator |
TAKENO Mitsuhiro Yokohama City University, 医学部, 准教授 (50236494)
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Atsuhisa 横浜市立大学, 附属病院, 准教授 (60295483)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ヘムオキシゲナーゼ-1 / Bach1 / 成人発症スティル病 / 血球貪食症候群 / ベーチェット病 / 破骨細胞 / アトピー性皮膚炎 / 白血病 / 肺癌 / 睡眠時無呼吸症候群 / 一酸化炭素 |
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| Research Abstract |
This project investigated pathogenic roles of heme oxygenase (HO)-1 in rheumatic and inflammatory diseases. We showed implication of defective HO-1expressoin in Behcet's disease, a protective role of HO-1 in atopic dermatitis, and serum HO-1 as a biomarker in hemophagocytic syndrome. Moreover, our studies revealed that HO-1 is involved in sleep apnea syndrome, osteoclastogenesis, tumor growth and acquired resistance to anticancer agents.
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