2010 Fiscal Year Final Research Report
Analysis of anti-neuronal antibodies in neuropsychiatric systemic lupus erythematosu
| Project/Area Number |
20591175
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kitasato University |
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Principal Investigator |
HIROHATA Shunsei Kitasato University, 医学部, 教授 (90189895)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAI Tatsuo 北里大学, 医学部, 講師 (60365947)
WADA Tatsuhiko 北里大学, 医学部, 助教 (60383585)
ENDO Hirahito 北里大学, 医学部, 准教授 (20213598)
MATSUI Toshimichi 北里大学, 医学部, 講師 (20348519)
HASHIMOTO Atsushi 北里大学, 医学部, 助教 (50327376)
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Tomohiro 聖マリアンナ医科大学, 医学部, 教授 (80233807)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 中枢神経ループス / ループス精神病 / 神経芽細胞腫細胞 / 抗神経細胞抗体 / エピトープ / プロテオミクス / ミトコンドリア酵素タンパク質 / 核酸結合タンパク質 |
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| Research Abstract |
In the current studies, we first demonstrated that cerebrospinal fluid anti-NR2 levels were significantly higher in patients with lupuspsychosis than in control groups, suggesting that anti-NR2 antibodies might play a pivotalrole in the pathogenesis of lupus psychosis. Using a proteomics approach, we next pickedup several antigens, including peroxiredoxin-4, ubiquitin carboxyl-terminal hydrolaseisozyme L1, splicing factor arginine/serine-rich 3, and histone H2A type 1, as candidates for the autoantigens of anti-neuronal antibodies. Finally, we disclosed that thatanti-ribosomal P antibodies induced Th1 responses by upregulating the production of IL-12 by activated monocytes.
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[Journal Article] Identification of autoantigens specific for systemic lupus erythematosus with central nervous system involvement.2010
Author(s)
Iizuka N, Okamoto K, Matsushita R, Kimura M, Nagai K, Arito M, Kurokawa MS, Masuko K, Suematsu N, Hirohata S, Kato T
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Journal Title
Peer Reviewed
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[Presentation] Determination of the accurate incidence of pulmonary arterial hypertension in patients with systemic sclerosis, mixed connective tissue disease and systemic lupus erythematosus by prospective study for 3 years.2010
Author(s)
Tanaka S, Hoshi K, Tanaka J, Wada T, Matsui T, Nagai T, Okada J, Hirohata S
Organizer
74th Annual Scientific Meeting
Place of Presentation
American College of Rheumatology, Atlanta, USA
Year and Date
2010-11-10
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[Presentation] Proteomic analysis of autoantigens in SLE patients with CNS involvement.2009
Author(s)
Iizuka N, Okamoto, K Matsushita R, Arito M, Nagai K, Kurokawa MS, Suematsu N, Masuko K, Hirohata S, Kato T
Organizer
73rd Annual Scientific Meeting
Place of Presentation
American College of Rheumatology, Phladelphia, USA
Year and Date
2009-10-19
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