2010 Fiscal Year Final Research Report
Clinical Significance of Adipocytokines in Rheumatoid Arthritis
| Project/Area Number |
20591177
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Toho University |
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Principal Investigator |
KAWAI Shinichi Toho University, 医学部, 教授 (70129401)
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| Project Period (FY) |
2008 – 2010
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| Keywords | リウマチ学 / 関節リウマチ / アディポサイトカイン |
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| Research Abstract |
Recent studies have demonstrated that adipocytokines secreted by adipocytes may have a role in the inflammatory process. We investigated their clinical significance in patients with rheumatoid arthritis (RA). We have reported that adiponectin stimulates the production of IL-8 (Biochem Biophys Res Commun. 2009 ; 378 : 218-223), and prostaglandin E2 (Arthritis Rheum. 2010 ; 62 : 1641-1649) by rheumatoid synovial fibroblasts in vitro. We also have reported that the serum levels of adiponectin, resistin, and leptin in RA patients were elevated (Intern Med. 2011 ; 50 : 269-275). These findings suggest that adipocytekines may, at least in part, contribute to synovial inflammation in RA.
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Research Products
(25 results)
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[Journal Article] Clinical and radiological features of acute-onset diffuse interstitial lung diseases in patients with rheumatoid arthritis receiving treatment with biological agents : importance of pneumocystis pneumonia in Japan revealed by a multicenter study.2011
Author(s)
Kameda H, Tokuda H, Sakai F, Johkoh T, Mori S, Yoshida Y, Takayanagi N, Taki H, Hasegawa Y, Hatta K, Yamanaka H, Dohi M, Hashimoto S, Yamada H, Kawai S, Takeuchi T, Tateda K, Goto H.
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Journal Title
Intern Med. 50
Pages: 305-313
Peer Reviewed
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[Journal Article] anti-interleukin-6-receptor antibody (tocilizumab) monotherapy is more effective in slowing radiographic progression in patients with rheumatoid arthritis at high baseline risk for structural damage evaluated with levels of biomarkers, radiography, and BMI : data from the SAMURAI study.2011
Author(s)
Hashimoto J, Garnero P, van der Heijde D, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Yoshikawa H, Nishimoto N. Humanized
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Journal Title
Mod Rheumatol. 21
Pages: 10-15
Peer Reviewed
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[Journal Article] Efficacy and safety of ketoprofen patch in patients with rheumatoid arthritis : a randomized, double-blind, placebo-controlled study.2010
Author(s)
Kawai S, Uchida E, Kondo M, Ohno S, Obata J, Nawata Y, Sugimoto K, Oribe M, Nagaya I.
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Journal Title
J Clin Pharmacol. 50
Pages: 1171-1179
Peer Reviewed
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[Journal Article] Systemic lupus erythematosus complicated by recurrent pneumothorax : case report and literature review.2010
Author(s)
Tanaka N, Kusunoki Y, Kaneko K, Yamamoto T, Kaburaki M, Muraoka S, Abe H, Endo H, Sato D, Homma S, Shibuya K, Kawai S.
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Journal Title
Jpn J Clin Immunol. 33
Pages: 162-168
Peer Reviewed
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[Journal Article] Japan College of Rheumatology 2009 guidelines for the use of tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody, in rheumatoid arthritis.2009
Author(s)
Koike R, Harigai M, Atsumi T, Amano K, Kawai S, Saito K, Saito T, Yamamura M, Matsubara T, Miyasaka N.
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Journal Title
Mod Rheumatol. 19
Pages: 351-357
Peer Reviewed
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