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2010 Fiscal Year Final Research Report

Analysis of repression mechanism by LECT2 in rheumatoid arthritis

Research Project

  • PDF
Project/Area Number 20591180
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

YAMAGOE Satoshi  National Institute of Infectious Diseases, 生物活性物質部, 主任研究官 (00212283)

Project Period (FY) 2008 – 2010
Keywords生理活性 / 免疫学 / サイトカイン / 自己免疫疾患
Research Abstract

We analyzed the repressive mechanism by LECT2 in rheumatoid arthritis. First, we have identified a LECT2 receptor-expressing cell type related in rheumatoid arthritis, and showed the possibility that human synoviocytes expressed the receptor of LECT2. Using those cells, we studied LECT2 effect on the proliferation of the cells, and expression of proinflammatory cytokines and several genes related to rheumatoid arthritis. We identified many genes controlled by main proinflammatory cytokines in a mouse model of rheumatoid arthritis.

  • Research Products

    (8 results)

All 2010 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Possible role of LECT2 as an intrinsic regulatory factor in SEA-induced toxicity in D-galactosamine-sensitized mice.2010

    • Author(s)
      Dang MH., Kato H., Ueshiba H., Omori-Miyake M, Yamagoe S., Ando K, Imanishi K., Arimura Y., Haruta I., Kotani T., Ozaki M., Suzuki K., Uchiyama T., Yagi J.
    • Journal Title

      Clin Immunol. 137

      Pages: 311-321

    • Peer Reviewed
  • [Journal Article] Identification and assignment of three disulfide bonds in mammalian leukocyte cell-derived chemotaxin 2 by matrix-assisted laser desorption/ionization time-of-flightmass spectrometry.2009

    • Author(s)
      Okumura A., Suzuki T., Dohmae N., Okabe T., Hashimoto Y., Nakazato K., Ohno H., Miyazaki Y., Yamagoe S.
    • Journal Title

      BioScience Trends. 3

      Pages: 139-43

    • Peer Reviewed
  • [Journal Article] マウスコラーゲン関節炎におけるLECT2(leukocyte cell-derived chemotaxin 2)の役割の解析2009

    • Author(s)
      奥村彰規、山越智
    • Journal Title

      リウマチ科 41

      Pages: 71-79

  • [Journal Article] Suppressive role of leukocyte cell-derived chemotaxin 2 in mouse anti-type II collagen antibody-induced arthritis.2008

    • Author(s)
      Okumura A., Saito T., Otani I., Kojima K., Yamada Y., Ishida-Okawara A., Nakazato K., Asano M., Kanayama K., Iwakura Y., Suzuki K., Yamagoe S.
    • Journal Title

      Arthritis Rheum. 58

      Pages: 413-421

    • Peer Reviewed
  • [Presentation] ガラクトサミン/LPS肝障害モデルを用いたLECT2の機能解析2009

    • Author(s)
      奥村彰規、大川原明子、山越智
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20091202-20091204
  • [Presentation] 敗血症におけるLECT2の役割2009

    • Author(s)
      大森深雪、安藤一義、上芝秀博、有村祐、山越智、鈴木和男、八木淳二
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20091202-20091204
  • [Presentation] Suppressive Role of LECT2 in Mouse Anti-Type-II Collagen Antibody-Induced Arthritis2008

    • Author(s)
      奥村彰規、大谷功、大川原明子、岩倉洋一郎、鈴木和男、山越智
    • Organizer
      第38回日本免疫学会総会学術集会
    • Place of Presentation
      京都
    • Year and Date
      20081201-20081203
  • [Patent(Industrial Property Rights)] 骨吸収抑制剤2009

    • Inventor(s)
      国立感染症研究所長、鈴木和男
    • Industrial Property Rights Holder
      鈴木和男、山越智、山川徹
    • Industrial Property Number
      特許第4378439号
    • Filing Date
      2009-10-02

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Published: 2012-01-26   Modified: 2016-04-21  

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