2010 Fiscal Year Final Research Report
Identification of mouse IL-25 receptor expressing cells
| Project/Area Number |
20591187
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kyushu University |
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Principal Investigator |
ARINOBU Yojiro Kyushu University, 大学病院・遺伝子細胞療法部 (90467928)
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| Co-Investigator(Kenkyū-buntansha) |
AKASHI Koichi 九州大学, 大学院・医学研究院, 教授 (80380385)
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| Project Period (FY) |
2008 – 2010
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| Keywords | IL-25 / IL-25 receptor / 好酸球前駆細胞 |
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| Research Abstract |
Interleukin-25 (IL-25) is one of the epithelial cell-derived cytokines which play critical roles in allergic inflammations, while it still remained unclear which cell populations express IL-25 receptor (IL-25R) and mediate its biological activities. In this study, we analyzed the expression level of IL-25R on all mouse hematopoietic cells and clarified that IL-25R is preferentially expressed on eosinophil progenitors (EoP). It was also suggested that IL-25 may act as a survival/proliferation factor for EoP.
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Research Products
(14 results)
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[Journal Article] Analysis of immune resonstitution after autologous CD34+ stem/progenitor cell transplantation for systemic sclerosis : predominant reconstitution of Th1 CD4+ T cells.2011
Author(s)
Tsukamoto H, Nagafuji K, Horiuchi T, Mitoma H, Niiro H, Arinobu Y, Inoue Y, To K, Miyamoto T, Iwasaki H, Teshima T, Harada M, Akashi K
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Journal Title
Rheumatology. 50
Pages: 944-952
Peer Reviewed
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[Journal Article] TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells.2010
Author(s)
Kikushige Y, Shima T, Takayanagi S, Urata S, Miyamoto T, Iwasaki H, Takenaka K, Teshima T, Tanaka T, Inagaki Y, Akashi K
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Journal Title
Cell Stem Cell. 7
Pages: 708-717
Peer Reviewed
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[Journal Article] Single pancreatic beta cells co-express multiple islet hormone genes in mice.2010
Author(s)
Katsuta H, Akashi T, Katsuta R, Nagaya M, Kim D, Arinobu Y, Hara M, Bonner-Weir S, Sharma AJ, Akashi K, Weir GC
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Journal Title
Diabetologia. 53
Pages: 128-138
Peer Reviewed
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[Journal Article] T cell leukemia/lymphoma 1 and galectin-1 regulate survival/cell death pathways in human naive and IgM+ memory B cells through altering balances in Bcl-2 family proteins.2009
Author(s)
Tabrizi SJ, Niiro H, Masui M, Yoshimoto G, Iino T, Kikushige Y, Wakasaki T, Baba E, Shimoda S, Miyamoto T, Hara T, Akashi K
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Journal Title
J Immunol 182
Pages: 1490-1499
Peer Reviewed
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[Journal Article] CD4 T-cell autoreacrivity to the mitochondrial autoantigen PDC-E2 in AMA-negative primary biliary cirrhosis.2008
Author(s)
Shimoda S, Miyakawa H, Nakamura M, Ishibiashi H, Kikuchi K, Kita H, Niiro H, Arinobu Y, Ono N, Mackay IR, Gershwin ME, Akashi K
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Journal Title
J Autoimmun 31
Pages: 110-115
Peer Reviewed
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