2010 Fiscal Year Final Research Report
Pathogenic and Clinical Significance of Myositis-specific Autoantibodies
| Project/Area Number |
20591194
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Keio University |
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Principal Investigator |
HIRAKATA Michito Keio University, 医学部, 准教授 (30199046)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 臨床免疫学 |
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| Research Abstract |
The inflammatory muscle diseases, polymyositis (PM) and dermatomyositis (DM) are systemic connective tissue disorders characterized by chronic inflammation in skeletal muscle and involvement of various systemic organs. Myositis-specific antibodies (MSAs) are closely associated with characteristic clinical features and therefore provide us useful information for diagnosis, patient classification as well as predict of signs, symptoms of myositis, response to treatment, and prognosis. Recently the nature of the target MSA autoantigens has been characterized using molecular biology and proteomic techniques. However, the mechanism of development of MSAs remains unknown. For understanding the pathogenic mechanisms of PM/DM, it is important to elucidate the relationship between these MSAs and their associated clinical entities. We have studied the clinical, immunogenetic, and histopathological features associated with MSAs (especially, anti-SRP and anti-aminoacyl-tRNA synthetase autoantibodies), developed the novel assay system for detecting anti-SRP antibodies, and identified novel MSA.
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[Journal Article] The association of a nonsynonymous single-nucleotide poly -morphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population.2010
Author(s)
Shimane K., Kochi Y., Horita T., Ikari K., Amano H., Hirakata M., Okamoto A., Yamada R., Nyouzzen K., Suzuki A., Kubo M., Atsumi T., Koike T., Takasaki Y., Momohara S., Yamanaka H., Nakamura Y., Yamamoto K.
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Journal Title
Arthritis Rheum. 62(2)
Pages: 574-9
Peer Reviewed
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[Journal Article] Clinical characteristics of cytomegalovirus infection in rheumatic diseases : Multicenter survey in a large patient population.2008
Author(s)
Takizawa Y., Inokuma S., Tanaka Y., Saito K., Atsumi T., Hirakata M., Kameda H., Hirohata S., Kondo H., Kumagai S., Tanaka Y.
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Journal Title
Rheumatology 47(9)
Pages: 1373-1378
Peer Reviewed
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[Journal Article] Clinical and radiological features of pneumocystis pneumonia in patients with rheumatoid arthritis, in comparison with methotrexate pneumonitis and pneumocystis pneumonia in acquired immunodeficiency syndrome : a multicenter study.2008
Author(s)
Tokuda H., Sakai F., Yamada H., Johkoh T., Imamura A., Dohi M., Hirakata M., Yamada T., Kamatani N., Kikuchi Y., Sugii S., Takeuchi T., Tateda K., Goto H.
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Journal Title
Intern Med. 47(10)
Pages: 915-23
Peer Reviewed
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