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2010 Fiscal Year Final Research Report

Targeting cryopyrin as a new therapeutic approach to control inflammation

Research Project

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Project/Area Number 20591197
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionDepartment of Clinical Research, National Hospital Organization Nagasaki Medical Center

Principal Investigator

MIGITA Kiyoshi  Department of Clinical Research, National Hospital Organization Nagasaki Medical Center, 臨床研究センター, 病因解析研究部長 (60264214)

Co-Investigator(Kenkyū-buntansha) ISHIBASHI Hiromi  独立行政法人国立病院機構長崎医療センター, 臨床研究センター, センター長 (80127969)
EGUCHI Katumi  長崎大学, 医歯薬学総合研究科, 教授 (30128160)
Project Period (FY) 2008 – 2010
Keywordsryopyrin / 自己炎症性疾患 / 家族性地中海熱 / 関節リウマチ / 血清アミロイドA蛋白
Research Abstract

The mechanism by which inflammasome activation and following IL-1β induction in autoinflammation is not completely elucidated. We studied the role of serum amyloid A (SAA) in the regulation of IL-1β production and activation of inflammasome cascade in human rheumatoid synoviocytes. Rheumatoid synoviocytes stimulated with SAA express NLRP3 (cryopyrin) mRAN expression. MSU (modosodium urate), a ligand for NLRP3, stimulation did not induce IL-1β production in rheumatoid synoviocytes. Whereas, rheumatoid synoviocytes pretreated with low concentration (1-5μg/ml) of SAA produce IL-1β in response to MSU. These findings indicate that during systemic inflammation, SAA may promote the MSU-induced IL-1β induction through activating the NLRP3 inflammasome activation.

  • Research Products

    (5 results)

All 2011 2010 2008 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Remarks (1 results)

  • [Journal Article] A Japanese case of familial Mediterranean fever presenting diffuse bone marrow uptake of FDG-PET and high levels of neutrophil membrane CD64 expression.2011

    • Author(s)
      Koga T, Umeda M, Migita K, Yamasaki S, Nakamura H, Kawakami A.
    • Journal Title

      Rheumatology (Oxford). 50(6)

      Pages: 1171-3

    • Peer Reviewed
  • [Journal Article] Protracted synovitis without systemic manifestations in familial Mediterranean fever (FMF).2010

    • Author(s)
      Migita K, Torigoshi T, Motokawa S, Ito M, Miyashita T, Izumi Y, Yasunami M.
    • Journal Title

      Clin Exp Rheumatol. 28(4 Suppl 60)

      Pages: S99

    • Peer Reviewed
  • [Journal Article] 家族性地中海熱2010

    • Author(s)
      上松一永, 右田清志
    • Journal Title

      医学のあゆみ2010 235(12,13)

      Pages: 1159-1163

    • Peer Reviewed
  • [Journal Article] MEFV mutations in Japanese rheumatoid arthritis patients.2008

    • Author(s)
      Migita K, Nakamura T, Maeda Y, Miyashita T, Koga T, Tanaka M, Nakamura M, Komori A, Ishibashi H, Origuchi T, Ida H, Kawasaki E, Yasunami M, Eguchi K.
    • Journal Title

      Clin Exp Rheumatol. 26(6)

      Pages: 1091-4

    • Peer Reviewed
  • [Remarks] ホームページ等

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Published: 2012-01-26   Modified: 2016-04-21  

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