2010 Fiscal Year Final Research Report
C.difficileフラジェリンが感染成立に果たす役割の研究
| Project/Area Number |
20591198
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Teikyo University |
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Principal Investigator |
OTA Yasuo Teikyo University, 医学部, 教授 (80292936)
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| Project Period (FY) |
2008 – 2010
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| Keywords | Clostridium difficile / フラジェリン / TLR5 / トキシンB / 下痢症 |
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| Research Abstract |
C. difficile is an important pathogen of nosocomial infection, and outbreak of C.difficile associated diseases (CDAD) often occurs in hospitals. However, the pathogenesis of CDAD remains to be determined. We investigated whether C. difficile flagellin were involved in the pathogenesis of CDAD. C. difficile flagellin induced activation of NF-kappaB and p38 mitogen-activated Protein Kinase (MAPK) via TLR5, and also promoted productions of Interleukin-8 (IL-8) and CCL20 in intestinal epithelial cells via TLR5. Pretreatment with toxin B stimulation enhanced production of CCL20 induced by C. difficile flagellin by increasing expressions of TLR5 in intestinal epithelial cells. These results collectively indicated that C. difficile flagellin plays an important role in the pathogenesis of CDAD.
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