2010 Fiscal Year Final Research Report

Novel oral vaccine using genetically engineering bifidobacterium displaying antigen on its cell-surface

Research Project

Project/Area Number	20591201
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Infectious disease medicine
Research Institution	Kobe University
Principal Investigator	SHIRAKAWA Toshiro Kobe University, 大学院・保健学研究科, 准教授 (70335446)
Co-Investigator(Kenkyū-buntansha)	SHIMADA Masaru 横浜市立大学, 大学院・医学研究科, 准教授 (40301452) KATAYAMA Tkakane 石川県立大学, 生物資源工学研究所, 准教授 (70346104)
Project Period (FY)	2008 – 2010
Keywords	ワクチン / 腸チフス / 粘膜免疫 / ビフィズス菌
Research Abstract	Genetically modified probiotic bacteria show promise as an antigen delivery vehicle for mucosal immunization. We developed a novel vaccine platform utilizing Bifidobacterium as an antigen delivery vehicle for mucosal immunization. Genetically modified Bifidobacterium longum displaying Salmonella-flagellin on the cell surface was constructed for the oral typhoid vaccine. We confirmed the efficacy of this oral vaccine in a murine typhoid fever model.

(4 results)