2010 Fiscal Year Final Research Report
Novel oral vaccine using genetically engineering bifidobacterium displaying antigen on its cell-surface
| Project/Area Number |
20591201
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Kobe University |
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Principal Investigator |
SHIRAKAWA Toshiro Kobe University, 大学院・保健学研究科, 准教授 (70335446)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Masaru 横浜市立大学, 大学院・医学研究科, 准教授 (40301452)
KATAYAMA Tkakane 石川県立大学, 生物資源工学研究所, 准教授 (70346104)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ワクチン / 腸チフス / 粘膜免疫 / ビフィズス菌 |
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| Research Abstract |
Genetically modified probiotic bacteria show promise as an antigen delivery vehicle for mucosal immunization. We developed a novel vaccine platform utilizing Bifidobacterium as an antigen delivery vehicle for mucosal immunization. Genetically modified Bifidobacterium longum displaying Salmonella-flagellin on the cell surface was constructed for the oral typhoid vaccine. We confirmed the efficacy of this oral vaccine in a murine typhoid fever model.
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