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2010 Fiscal Year Final Research Report

Screening of excreted proteins of Aspergillus fumigates for clinical application.

Research Project

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Project/Area Number 20591212
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Infectious disease medicine
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

MIYAZAKI Yoshitsugu  National Institute of Infectious Diseases, 生物活性物質部, 部長 (00311861)

Co-Investigator(Kenkyū-buntansha) IZUMIKAWA Kouichi  長崎大学, 医歯薬学総合研究科, 助教 (20404212)
YAMAGOE Satoshi  国立感染症研究所, 生物活性物質部, 主任研究官 (00212283)
Project Period (FY) 2008 – 2010
KeywordsAspergillus属 / 診断
Research Abstract

We found some novel fungal proteins which natively exist on cell surface or are excreted out through cell membrane. Candidate proteins were chosen depending on levels of transcription for further experiments of gene cloning and of producing antibody, then confirmed that some proteins could be detected in culture medium. That showed those candidate, or at least a part of those, are excreted out to medium from fungal cell. We developed a preliminary diagnostic kit as an application of the study.

  • Research Products

    (11 results)

All 2011 2010 2009

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (1 results)

  • [Journal Article] Transcription factors CgUPC2A and CgUPC2B regulate ergosterol biosynthetic genes in Candida glabrata.2011

    • Author(s)
      Nagi M, Nakayama H, Tanabe K, Bard M, Aoyama T, Okano M, Higashi S, Ueno K, Chibana H, Niimi M, Yamagoe S, Umeyama T, Kajiwara S, Ohno H, Miyazaki Y
    • Journal Title

      Genes Cells. 16

      Pages: 80-89

    • Peer Reviewed
  • [Journal Article] Intravenous micafungin versus voriconazole for chronic pulmonary aspergillosis : a multicenter trial in Japan.2010

    • Author(s)
      Kohno S, Izumikawa K, Ogawa K, Kurashima A, Okimoto N, Amitani R, Kakeya H, Niki Y, Miyazaki Y
    • Journal Title

      J Infect 61(5)

      Pages: 410-418

    • Peer Reviewed
  • [Journal Article] Monooxygenation of rifampicin catalyzed by the rox gene product of Nocardia farcinica : structure elucidation, gene identification and role in drug resistance.2010

    • Author(s)
      Hoshino Y, Fujii S, Shinonaga H, Arai K, Saito F, Fukai T, Satoh H, Miyazaki Y, Ishikawa J
    • Journal Title

      J Antibiot. 63(1)

      Pages: 23-28

    • Peer Reviewed
  • [Journal Article] Posaconazole for chronic pulmonary aspergillosis : The next strategy against the threat of azole-resistant Aspergillus infection.2010

    • Author(s)
      Kohno S, Izumikawa K
    • Journal Title

      Clin Infect Dis. 51

      Pages: 1392-1394

    • Peer Reviewed
  • [Journal Article] Micafungin alters the expression of genes related to cell wall integrity in Candida albicans biofilms.2010

    • Author(s)
      Kaneko Y, Ohno H, Kohno S, Miyazaki Y
    • Journal Title

      Jpn J Infect Dis. 63(5)

      Pages: 355-357

    • Peer Reviewed
  • [Journal Article] Anti-Candida-biofilm activity of micafungin is attenuated by voriconazole but restored by pharmacological inhibition of Hsp90 related stress responses.2010

    • Author(s)
      Kaneko Y, Ohno H, Fukazawa H, Murakami Y, Imamura Y, Kohno S, Miyazaki Y
    • Journal Title

      Med Myocol. 48(4)

      Pages: 606-612

    • Peer Reviewed
  • [Journal Article] An outbreak of histoplasmosis among healthy young Japanese women after traveling to Southeast Asia.2010

    • Author(s)
      Ohno H, Ogata Y, Suguro H, Yokota S, Watanabe A, Kamei K, Yamagoe S, Ishida-Okawara A, Kaneko Y, Horino A, Yamane K, Tsuji T, Nagata N, Hasegawa H, Arakawa Y, Sata T, Miyazaki Y
    • Journal Title

      Inter Med. 49

      Pages: 491-495

    • Peer Reviewed
  • [Journal Article] Serum or bile affects the in vitro azole susceptibilities of Candida spp.2009

    • Author(s)
      Nagi M, Tanabe K, Takano Y, Kikuchi K, Miyazaki Y, Niimi M
    • Journal Title

      Jpn J Infect Dis. 62(4)

      Pages: 306-308

    • Peer Reviewed
  • [Journal Article] The effects of an hsp90 inhibitor on the paradoxical effect.2009

    • Author(s)
      Kaneko Y, Ohno H, Imamura Y, Kohno S, Miyazaki Y
    • Journal Title

      Jpn J Infect Dis. 62(5)

      Pages: 392-393

    • Peer Reviewed
  • [Journal Article] Pulmonary cryptococcosis in late pregnancy and review of published literature.2009

    • Author(s)
      Nakamura S, Izumikawa K, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Miyazaki Y, Kohno S
    • Journal Title

      Mycopathologia. 167(3)

      Pages: 125-131

    • Peer Reviewed
  • [Presentation] Aspergillus fumigatus分泌蛋白質Y-1を標的としたELISA検出系の構築と病原性の検討2010

    • Author(s)
      山越智,橋本ゆき,梅山隆,田辺公一,金子幸弘,大野秀明,宮崎義継
    • Organizer
      第54回日本医真菌学会総会
    • Place of Presentation
      東京
    • Year and Date
      20101016-20101017

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

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