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2010 Fiscal Year Final Research Report

Association of gene polymorphism with vitamin D deficiency.

Research Project

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Project/Area Number 20591215
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionYamagata University

Principal Investigator

KITANAKA Sachiko  Yamagata University, 医学部附属病院, 准教授 (30431638)

Co-Investigator(Kenkyū-buntansha) NUMAKURA Chikahiko  山形大学, 医学部, 助教 (00400549)
Project Period (FY) 2008 – 2010
KeywordsビタミンD欠乏症 / くる病 / 疾患感受性遺伝子 / ゲノム / 遺伝子多型
Research Abstract

Vitamin D deficiency resulting in hypocalcemic seizures or rickets in children is increasing worldwide, due to an insufficient intake of vitamin D and a lack of sunshine exposure. Since the prevalence of vitamin D deficiency is low compared to the large number of breastfed children with low serum levels of 25OHD, we speculated that some genetic predisposition may be concerned with the onset of vitamin D deficiency. In this study, we analyzed polymorphisms in vitamin D related genes in patients with vitamin D deficiency and controls in Japan. We found differences in the polymorphisms, suggesting that genetic factors may predispose to vitamin D deficiency to some extent.

  • Research Products

    (18 results)

All 2011 2010 2009 2008 2007 Other

All Journal Article (8 results) (of which Peer Reviewed: 3 results) Presentation (6 results) Book (3 results) Remarks (1 results)

  • [Journal Article] 乳幼児のビタミンD欠乏 診断の指針・治療の指針2011

    • Author(s)
      北中幸子
    • Journal Title

      綜合臨床 60

      Pages: 306-307

  • [Journal Article] 骨を丈夫にするためには~骨を丈夫にする運動はあるのか~2011

    • Author(s)
      北中幸子
    • Journal Title

      チャイルドヘルス 14

      Pages: 1034-1037

  • [Journal Article] Supernumerary impacted teeth in a patient with SOX2 anophthalmia syndrome.2010

    • Author(s)
      Numakura C, Kitanaka S, Kato M, Ishikawa S, Hamamoto Y, Katsushima Y, Kimura T, Hayasaka K.
    • Journal Title

      Am J Med Genet Part A 152A

      Pages: 2355-2359

    • Peer Reviewed
  • [Journal Article] 成長障害2010

    • Author(s)
      北中幸子
    • Journal Title

      小児科学レビュー(総合医学社) 2010

      Pages: 147-152

  • [Journal Article] 遺伝性くる病2010

    • Author(s)
      北中幸子
    • Journal Title

      Clinical Calcium 20

      Pages: 1238-1244

  • [Journal Article] 幼児の低身長2010

    • Author(s)
      北中幸子
    • Journal Title

      小児科 51

      Pages: 1469-1474

  • [Journal Article] Role of HNF-1・ and HNF-1・ on insulin, IGF-1, and other potential target genes.2008

    • Author(s)
      Kitanaka S.
    • Journal Title

      Expert Rev.Endocrinol.Metab. 3(4)

      Pages: 441-452

    • Peer Reviewed
  • [Journal Article] Regulation of human insulin, IGF-I, and multidrug resistance protein 2 promoter activity by hepatocyte nuclear factor (HNF)-1・ and HNF-1・ and the abnormality of HNF-1・ mutants.2007

    • Author(s)
      Kitanaka S, Sato U, Igarashi T.
    • Journal Title

      Journal of Endocrinology 192

      Pages: 141-147

    • Peer Reviewed
  • [Presentation] ビタミンD欠乏症の発症に関連する遺伝子の解析2011

    • Author(s)
      北中幸子, 他
    • Organizer
      第114回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20110812-20110814
  • [Presentation] ビタミンD欠乏症と関連する遺伝子多型の解析2011

    • Author(s)
      北中幸子, 他
    • Organizer
      第84回日本内分泌学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      20110421-20110423
  • [Presentation] Molecular analyses of vitamin D 25-hydroxylase gene in patients with vitamin D deficiency.2010

    • Author(s)
      S. Kitanaka, et al.
    • Organizer
      International Symposium on Pediatric Endocrinology.
    • Place of Presentation
      Tokyo
    • Year and Date
      20100331-20100401
  • [Presentation] Association of vitamin D receptor gene polymorphism with vitamin D deficiency.2010

    • Author(s)
      S. Kitanaka, et al.
    • Organizer
      14 International Congress of Endocrinology.
    • Place of Presentation
      Kyoto
    • Year and Date
      20100326-20100330
  • [Presentation] ビタミンD欠乏症におけるビタミンD25水酸化酵素遺伝子解析2009

    • Author(s)
      北中幸子, 他
    • Organizer
      第27回小児代謝性骨疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-12-05
  • [Presentation] ビタミンD欠乏症の疾患感受性遺伝子の解析2008

    • Author(s)
      北中幸子, 他
    • Organizer
      第42回日本小児内分泌学会
    • Place of Presentation
      米子
    • Year and Date
      20081002-20081004
  • [Book] 新生児内分泌学 カルシウム代謝 小児内分泌学(日本小児内分泌学会編)2009

    • Author(s)
      北中幸子
    • Total Pages
      141-144
    • Publisher
      診断と治療社
  • [Book] ビタミンD依存性くる病「小児の骨の発達とその異常性」(藤枝憲二、田中弘之編)2008

    • Author(s)
      北中幸子
    • Total Pages
      160-166, 320
    • Publisher
      診断と治療社
  • [Book] メディカルサイエンスインターナショナル2008

    • Author(s)
      北中幸子
    • Total Pages
      151
    • Publisher
      成長障害と体重増加不良、低身長と身長増加不良 一目でわかる小児科学第2版 五十嵐隆監訳
  • [Remarks] ホームページ等

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Published: 2012-01-26   Modified: 2016-04-21  

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