2010 Fiscal Year Final Research Report
The association of IGFBP-1 gene polymorphism with height growth and insulin sensitivity
| Project/Area Number |
20591216
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KAMODA Tomohiro University of Tsukuba, 大学院・人間総合科学研究科, 准教授 (50224704)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZONO Yayoi 筑波大学, 大学院・人間総合科学研究科, 講師 (30400675)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 遺伝子 / 内科 / 臨床 |
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| Research Abstract |
IGFBP-1 gene polymorphism (A4403G) was analyzed in children with idiopathic short stature and the association of its genotype with blood IGFBP-1 or free IGF-I levels was evaluated. The results showed no significant association between A4403G genotype and blood free IGF-I levels, suggesting that the differences in the binding ability of IGFBP-1 for circulating IGF-I was unlikely to explain the etiology of idiopathic short children.
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