2010 Fiscal Year Final Research Report
Experimental study of immune responses in cell transplantation therapy for genetic neurodegenerative disorders
| Project/Area Number |
20591229
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Osaka City University |
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Principal Investigator |
TANAKA Akemi Osaka City University, 大学院・医学研究科, 准教授 (30145776)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Mitsuyo 大阪歯科大学, 大学院・医学研究科, 助教 (40122080)
SETO Toshiyuki 大阪市立大学, 大学院・医学研究科, 講師 (60423878)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 神経遺伝性疾患 / 細胞移植 / 免疫応答 / 移植免疫 / 再生医療 |
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| Research Abstract |
We performed cell transplantation therapy to treat the brain involvement of lysosomal storage diseases. The grafted cells were gradually depleted because of immunological rejection by the host animals. To avoid deleterious immune attack and to achieve sufficient long-term efficacy in brain, development of methods to steer the immune response away from cytotoxic responses or to induce tolerance to the products of therapeutic genes is needed. To overcome this immunological rejection, we carried out brain injection and intravenous administration of mesenchymal stem cells simultaneously to a model mouse of β-galactosidase deficiency. However, we could not show a significant deference in the duration of engrafting between the brain injection only and the simultaneous injection of brain and vein.
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[Journal Article] Mucolipidosis II and III alpha/beta : mutation analysis of 40 Japanese patients showed genot ype-phenotype correlation.2009
Author(s)
Otomo T, Muramatu T, Yorifuji T, Oku yama T, Nakabayashi H, Fukao T, Oh ura T, Yoshino M, Tanaka A, Okamoto N, Ozono K, Sakai N.
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Journal Title
J Hum Ge net 54
Pages: 145-151
Peer Reviewed
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[Presentation] Efficacy of hematopoietic cell transplantation on the patients with mucopolysaccharidosis type II : Multicenter survey in Japan.2010
Author(s)
Tanaka A, Okuyama T, Suzuki Y, Sakai N, Sawada T, Tanaka T, Takakura H, Ohashi T, Wada M, Yabe H, Ohura T, Suzuki N, Kato K, Adachi S, Mugishima H, Kato S
Organizer
11^<th> International Symposium on Mucopolysaccharide and Related Diseases
Place of Presentation
Adelaide, Australia
Year and Date
20100622-20100627
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[Book] Neurochemistry of Metabolic Disease, Chaptor 8: Enzyme Replacement Therapy for Lysosomal Storage Dseases. Editors: Sanker Surendran2011
Author(s)
Tomatsu S, Montano AM, Molano ACS, Roman D, Hintze J, Carvalho CG, Federhen A, Vieira TA, Giugliani R, Wegrzyn G, Tanaka A, Suzuki Y, Orii T.
Publisher
Nova Science Publishers, Inc. in press
