2010 Fiscal Year Final Research Report
The role of the mitochondrial targeting signal in the function of steroidogenic acute regulatory protein revealed by BAC transgenesis in vivo
| Project/Area Number |
20591231
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
ISHII Tomohiro Keio University, 医学部, 助教 (70265867)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | steroidogenic acute regulatory protein / ステロイドホルモン / 細菌人工染色体(BAC) / トランスジェニックマウス / ミトコンドリア標的シグナル |
|---|
| Research Abstract |
The present study clarified the mechanism of steroidogenic acute regulatory protein (StAR) that transfers cholesterol from the outer to the inner mitochondrial membrane in the first step of acute steroidogenesis. It demonstrated the important role of mitochondrial entry of StAR by its mitochondrial targeting signal on the function of the StAR in vivo.
|
