2010 Fiscal Year Final Research Report
Postnatal development of the brain- adipose axis and its abnormality : as the background of the metabolic syndrome
| Project/Area Number |
20591236
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
YAMAMOTO Yukiyo University of Occupational and Environmental Health, Japan, 医学部, 講師 (20279334)
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| Co-Investigator(Kenkyū-buntansha) |
DOBASHI Kazushige 昭和大学, 医学部, 講師 (60260569)
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| Project Period (FY) |
2008 – 2010
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| Keywords | Nesfatin-1 / 室傍核 / 弓状核 / 摂食調節 / 生後発達 / 脳脂肪細胞系 / 視床下部 / 視索上核 |
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| Research Abstract |
To begin to understand the physiological role of Nesfatin-1 during postnatal development, we examined the developmental changes of the Nesfatin-1 gene expression in the PVN, SON and ARC during postnatal day 1 to day 60, using in situ hybridization histochemistry. Development of Nesfatin-1, which showed different patterns each hypothalamic nucleus during postnatal development, may be associated with its region-specific roles during postnatal development.Next, we examined the effect of the maternal deprivation for twenty-four hours on the gene expression of the Nesfatin-1 during pre-weaning period. After 24 h milk deprivation, the Nesfatin-1 gene expression was significantly increased at postnatal day 15. Significant increase in the expression of the Nesfatin-1 gene after milk deprivation suggested that osmolality change induced by milk deprivation might be a stimulant to induce the expression of the Nesfatin-1 gene in the preweaning period. Development of Nesfatin-1 may be associated with its critical role in the maturation of neurosecretory function in the hypothalamus-pituitary axis.
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