2010 Fiscal Year Final Research Report
Effects of prenatal chemical substance exposure on the neurofunctions at the stage of CNS formation and neurobehavior at juvenile period.
| Project/Area Number |
20591237
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
UENO Susumu University of Occupational and Environmental Health, Japan, 医学部, 准教授 (00279324)
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| Co-Investigator(Kenkyū-buntansha) |
FUETA Yukiko 産業医科大学, 産業保健学部, 助教 (10132482)
YUHI Tomoaki 産業医科大学, 医学部, 助教 (60330982)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 小児神経学 |
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| Research Abstract |
In this research project, we investigated the effect of prenatal exposure to 1-bromopropane (1BP), an alternative to chlorofluorocarbons, on the neurofunctions at the CNS-formation stage and neurobehavior at juvenile period, using rat animal models. As a result, we found that prenatal exposure to 1BP may alter hippocampal stimulus-responsive relationship at the CNS-formation stage, and exploration and short-term memory function at the juvenile period, suggesting that the prenatal exposure to chemicals could induce a postgrowth abnormality of neurobehavior.
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