2010 Fiscal Year Final Research Report
Epileptogenesis of refractory epilepsy in acute and chronic child-onset neurological disorders
| Project/Area Number |
20591238
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
HAYASHI Masaharu Tokyo Metropolitan Organization for Medical Research, 東京都神経科学総合研究所, 副参事研究員 (00280777)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 難治てんかん / 髄液マーカー / ELISA / 剖検脳 / 免疫組織化学染色 / 脳炎・脳症 / 酸化ストレス / アセチルコリン神経 |
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| Research Abstract |
In order to clarify the pathogenesis of child-onset intractable epilepsy, we performed ELISA analysis in the cerebrospinal fluid (CSF), and immunohistochemical study in the autopsy brains. We identified the involvements of axonal damage and oxidative stress in patients with acute encephalopathy with biphasic seizures and clinically mild encephalopathy with a reversible splenial lesion, respectively. We found the lesion of acetylcholine neurons in the pedunculopontine tegmental nucleus in cases of perinatal disorders, sequels of West syndromes, and dentatorubropallidoluysian atrophy. We also discovered the impairment of the cortical GABAergic interneurons in cases of mucopolysaccharidosis and diffuse cortical dysplasia.
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