2010 Fiscal Year Final Research Report
Clinical significance of WASP protein complex in nucleus.
| Project/Area Number |
20591242
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
SASAHARA Yoji Tohoku University, 病院, 講師 (60372314)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | WASP / WIP / 原発性免疫不全症 / Wiskott-Aldrich症候群 |
|---|
| Research Abstract |
Constitutively activating WASP causes X-linked neutropenia and myelodysplastic syndrome. We have identified that WASP played a significant role in transcriptional regulation of myeloid cell differentiation in nucleus. We also clarified that WIP formed a complex with WASP and regulated WASP protein stability, leading us to understand molecular pathogenesis of new type of WAS.
|
