2010 Fiscal Year Final Research Report
Computational leukemic stem cell models in systems biology for predicting relapse and development of risk-stratified chemotherapy
| Project/Area Number |
20591248
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
SAIKAWA Yutaka Kanazawa Medical University, 医学部, 教授 (60283107)
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| Co-Investigator(Kenkyū-buntansha) |
KOMATSUZAKI Toshihiko 金沢大学, 機械工学系, 准教授 (80293372)
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| Project Period (FY) |
2008 – 2010
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| Keywords | システム生物学 / 白血病幹細胞 / コンピューターシミュレーション / セルラオートマトン |
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| Research Abstract |
We constructed the 3-dimmensional computer simulation system for investigation of cellular dynamics in normal granulopoiesis. Granulocytic cell dynamics under the simulation of chemotherapy and G-CSF rescue fitted well to the cell behavior under clinical situations. A model of acute myelogenous leukemia was simulated by means of introducing leukemic stem cell systems.
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