2010 Fiscal Year Final Research Report
The cytotoxic effect by natural killer cells against pediatric malignant tumors.
| Project/Area Number |
20591249
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Yamanashi |
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Principal Investigator |
GOI Kumiko University of Yamanashi, 大学院・医学工学総合研究部, 助教 (70324192)
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| Co-Investigator(Kenkyū-buntansha) |
OSHIRO Hiroko 山梨大学, 医学部附属病院, 医員 (50377537)
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| Project Period (FY) |
2008 – 2010
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| Keywords | NK細胞 / 難治性腫瘍 / 白血病 / KIR / 同種移植 |
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| Research Abstract |
We analyzed the effect and the mechanisms of the cytotoxicity of the peripheral blood (PB) and the cord blood (CB) NK cells against pediatric leukemia and solid tumors. If donor KIR (killer cell Ig-like receptor) ligand is not present in the tumor cells, alloreactivity against the recipients' tumor cells is increased in MLL rearranged acute lymphoblastic leukemia and T-cell acute lymphoblastic leukemia. Therefore the graft versus tumor effect against these malignancies could be considerably expected if the KIR ligand incompatible donor is selected for CBT.
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