2010 Fiscal Year Final Research Report
Pathogenesis and clinical course of primary antibody deficiency
Project/Area Number |
20591250
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Gifu University |
Principal Investigator |
KANEKO Hideo Gifu University, 大学院・医学系研究科, 教授 (80293554)
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Project Period (FY) |
2008 – 2010
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Keywords | 高IgM症候群 / activation induced cytidine deaminase / R190X変異 / Dominant negative mutation / 体細胞突然変異 |
Research Abstract |
The pattern of serum Ig level were different between mother and daughter with same AID mutation (R190X). The immune phenotype of HIGM2 (R190X) might be affected by the environmental factors or the other genetic factors. In HIGM2 (R190X), specific antibody of IgM class was expressed for long time by IgM memory B cells, in which have done somatic hypermutation. In HIGM2 (R190X), some B cell could switched IgM to IgG. This switched B cell might not survive for long time and IgG antibody might become disappeared.
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[Journal Article] The response of bovine beta-lactoglobulin-specific T-cell clones to single amino acid substitution of T-cell core epitope.2008
Author(s)
Kondo M, Kaneko H, Fukao T, Suzuki K, Sakaguchi H, Shinoda S, Kato Z, Matsui E, Teramoto T, Nakano T, Kondo N.
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Journal Title
Pediatr Allergy Immunol. 19
Pages: 592-598
Peer Reviewed
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[Journal Article] A novel polymorphism, E254K, in the 5-lipoxygenase gene associated with bronchial asthma.2008
Author(s)
Bai C, Matsui E, Ohnishi H, Kimata K, Kasahara K, Kaneko H, Kato Z, Fukao T, Kondo N.
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Journal Title
Int J Mol Med. 21
Pages: 139-144
Peer Reviewed
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[Book] volume 1 Allergy Frontiers : Epigenetics, Allergens and Risk Factors(Allergy Frontiers)(In : Pawankar R, Holgate ST, Rossenwasser LJ eds.)2009
Author(s)
Kondo N, Matsui E, Kaneko H, Fukao T, Teramoto T, Kato Z, Ohnishi H, Nishimura A : Genetics of Pediatric Asthma.
Total Pages
189-203