2010 Fiscal Year Final Research Report
Basic study for establishment of novel antibody therapy for hemophilia A with an antibody enhancing factor VIII activity
| Project/Area Number |
20591259
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nara Medical University |
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Principal Investigator |
SHIMA Midori Nara Medical University, 医学部, 教授 (30162663)
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| Co-Investigator(Kenkyū-buntansha) |
SHIBATA Masaru 奈良県立医科大学, 医学部, 講師 (50405388)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 小児血液学 |
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| Research Abstract |
Antibodies that promote FVIII activity do not appear to have been reported. In this study, anti-FVIII monoclonal antibody, mab216, that enhanced FVIII coagulation activity. The mab216 increased FVIII activity ～1.5-fold dose-dependently, FXa generation and thrombin generation were increased by ～1.4- and ～2.5-fold, respectively. An anti A2 epitope was identified and the antibody enhanced the cleavage at Arg372. The findings may cast new light on new principles for improving the treatment of haemophilia A patients.
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[Journal Article] Correlations between global clotting function tests, duration of operation, and postoperative chest tube drainage in pediatric cardiac surgery.2011
Author(s)
Hayashi T, Sakurai Y, Fukuda K, Yada K, Ogiwara K, Matsumoto T, Yoshizawa H, Takahashi Y, Yoshikawa Y, Hayata Y, Taniguchi S, Shima M.
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Journal Title
Paediatr Anaesth(Epub)
Pages: doi: 10.1111/j.1460-9592.2011.03524.x.
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[Journal Article] T hrombin generation by intimal tissue factor contributes to thrombus formation on macrophage-rich neointima but not normal intima of hyperlipidemic rabbits.2009
Author(s)
Yamashita A, Matsuda S, Matsumoto T, Moriguchi-Goto S, Takahashi M, Sugita C, Sumi T, Imamura T, Shima M, Kitamura K, Asada Y.
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Journal Title
Atherosclerosis 206(2)
Pages: 418-426
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