2010 Fiscal Year Final Research Report
Molecular and cellular biological study on the mechanism of spontaneous remission of transient myeloproliferative disorder in children with Down syndrome
| Project/Area Number |
20591263
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
MIYAUCHI Jun Tokyo Dental College, 歯学部, 教授 (20146707)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAGUCHI Hiroyuki 東邦大学, 医学部・小児科, 講師 (00313130)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ダウン症候群 / 一過性骨髄増殖症 / 自然治癒 / 造血因子 / 造血微小環境 / 分化 / GATA1 / 遺伝子変異 |
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| Research Abstract |
Transient myeloproliferative disorder (TMD) in neonates with Down syndrome is a special leukemia that arises in fetal stage and spontaneously regresses after birth. We studied the role of hematopoietic microenvironment in spontaneous remission of TMD. In the presence of growth factors, TMD blasts differentiated into basophil/mast cell and megakaryocyte lineages and aberrant expression of GATA1 protein due to GATA1 mutations was shown to be down-regulated during differentiation. The growth of TMD blasts was maintained by stromal cells of the fetal liver. These data indicate that differentiation potential of TMD blasts and fetal hematopoietic microenvironment could be involved in spontaneous remission of TMD.
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Research Products
(45 results)
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[Journal Article] Fulminant hepatic failure as the initial manifestation of small-cell lung cancer: Report of 2 cases.2008
Author(s)
Terashima T, Matsuzaki T, Ogawa R, Naitou A,Inokuchi S, Kaida S, Kishikawa H, Nishida J, Tanaka Y, Miyauchi J, Morishita T, Ishizaka A
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Journal Title
Ann.Cancer Res.Therap. 16(1)
Pages: 16-30
Peer Reviewed
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