2010 Fiscal Year Final Research Report
The mechanism of development and exacerbation of virus-induced asthma analyzed by a lipid mediator gene knock-out mice
| Project/Area Number |
20591267
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Gunma Institute of Public Health and Environmental Sciences |
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Principal Investigator |
KATO Masahiko Gunma Institute of Public Health and Environmental Sciences, 研究企画係, 研究員 (30292593)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Yoshiyuki 群馬県衛生環境研究所, 研究企画係, 研究員 (80309252)
HAYASHI Yasuhide 群馬県衛生環境研究所, 研究企画係, 研究員 (30238133)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 小児免疫 / アレルギー / 膠原病学 |
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| Research Abstract |
To clarify the pathogenesis of exacerbations of asthma due to viral infection, we examined bronchial resistance, peripheral blood and bronchial alveolar fluid (BALF) analyses and multiple types of cytokines/chemokines using an experimental asthma model mice infected with respiratory syncytial virus (RSV). The levels of BALF and tissue eosinophils showed significant increase in ovalbumin (OVA) and OVA/RSV groups compared with controls. MIP-1αin BALF was significantly increased in OVA/RSV groups compared with RSV groups, OVA groups, and control groups. Serum IL-5 in OVA groups and serum IL-17 in OVA/RSV groups were also higher than in controls. These findings suggest that eosinophilic inflammation via MIP-1α may play an important role in acute exacerbations of asthma model induced by RSV.
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Research Products
(18 results)
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[Journal Article] Prominent eosinophilia but less eosinophil activation in a patient with Omenn syndrome.2010
Author(s)
Seki M, Kimura H, Mori A, Shimada A, Yamada Y, Maruyama K, Hayashi Y, Agematsu K, Morio T, Yachie A, Kato M
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Journal Title
Pediatr Int 52
Pages: e196-e199
Peer Reviewed
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[Presentation] Rhinovirus enhances eosinophil activation through the production of IL-5 in acute exacerbation of childhood asthma.2009
Author(s)
Kato M, Tsukagoshi H, Yoshizumi M, Saitoh M, Kozawa K, 山田佳之, Maruyama K, 林泰秀, Kimura H
Organizer
65th Annual meeting of American Allergy, Asthma and Immunology.
Place of Presentation
Washington, DC, USA
Year and Date
2009-03-17
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