2010 Fiscal Year Final Research Report
Regulation of Mash1 transcription and cell growth by genes identified in gene expression analysis of cancer
| Project/Area Number |
20591268
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
ISOGAI Eriko Chiba Cancer Center (Research Institute), 臨床ゲノムセンター・がんゲノム研究室, 上席研究員 (40300917)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 神経芽腫 / 神経発生 |
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| Research Abstract |
Mash1 is transiently and permanently expressed in normal developmental process and in neuroblastoma, respectively. In this study, it was suggested that LIM-only protein, LMO3 and bHLH protein, HEN2, that are highly expressed in unfavorable neuroblastoma, cooperate for promoting Mash1 transcription and development of neuroblastoma through interfering with the function of HES1, a negative regulator of Mash1 transcription.
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