2010 Fiscal Year Final Research Report
The role of reactive oxygen species (ROS) in the progressive kidney disease in children, and therapeutic strategy based on its mechanisms.
| Project/Area Number |
20591278
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KAGAMI Shoji The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (00224337)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Shuji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (00380080)
ROKUTAN Kazuhito 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (10230898)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 小児腎・泌尿器学 / メサンギウム細胞 / ポドサイト / ボウマン嚢上皮細胞 / 半月体 / 活性酸素 / NAD(P)Hオキシダーゼ / 腎炎進行 / 腎不全 |
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| Research Abstract |
The role of reactive oxygen species for cell phenotypic changes was investigated in glomerulonephritis (GN). Increased ROS production was observed in crescents of GN. The increased ROS production was associated with enhanced Nox2 (an NADPH component) expression and parietal epithelial cell proliferation. We also observed the expressions of angiotensin II and its receptor. In addition, cultured glomerular cells stimulated with angiotensin II and H2O2 showed the enhanced phosphorylation of Erk5, a ROS-related MAPK family. Inhibition with siRNA showed that ROS-MAP kinase signaling pathway might enhance cell potential to survive, and thereby play a role in progression of glomerulonephritis.
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[Journal Article] Angiotensin II type I receptor blockade suppresses glomerular RAS activation, oxidative stress, and glomerular injury in crescentic glomerulonephritis.2011
Author(s)
Kinoshita Y, Kondo S, Urushihara M, Suga K, Matsuura S, Takamatsu M, Shimizu M, Nishiyama A, Kawachi H, Kagami S
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Journal Title
Translational Res (in press)
Peer Reviewed
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[Journal Article] ERK5 activation enhances mesangial cell viability and collagen matrix accumulation in rat progressive glomerulonephritis.2010
Author(s)
Urushihara M, Takamatsu M, Shimizu M, Kondo S, Kinoshita Y, Suga K, Kitamura A, Matsuura S, Yoshizumi M, Tamaki T, Kawachi H, Kagami S
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Journal Title
Am J Physiol Renal Physiol. 298
Pages: F167-176
Peer Reviewed
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[Journal Article] Dietary doses of nitrite restore circulating nitric oxide level and improve renal injury in L-NAME-induced hypertensive rats.2008
Author(s)
Kanematsu Y, Yamaguchi K, Ohnishi H, Motobayashi Y, Ishizawa K, Izawa Y, Kawazoe K, Kondo S, Kagami S, Kagami S, Tsuchiya K, Tamaki T.
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Journal Title
Am J Physiol Renal Physiol. 295
Pages: F1457-1462
Peer Reviewed
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