2010 Fiscal Year Final Research Report
New evaluation for severity of Kawasaki disease using HMGB1 values.
| Project/Area Number |
20591281
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kagoshima University |
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Principal Investigator |
NOMURA Yuichi Kagoshima University, 医歯学総合研究科, 准教授 (90237884)
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| Co-Investigator(Kenkyū-buntansha) |
NISHI Junichiro 鹿児島大学, 医学部・歯学部附属病院, 講師 (40295241)
HASHIGUCHI Teruto 鹿児島大学, 医歯学総合研究科, 准教授 (70250917)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 川崎病 / 重症度 / 冠動脈後遺症 / 免疫グロブリン治療 / 不応例 / Gunmaスコア |
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| Research Abstract |
We examined the efficacy of high mobility group box 1 (HMGB1) value for evaluating the severity of KD. Methods : Serum HMGB1 values were compared between the responders (143 patients) to initial intravenous immunoglobulin (IVIG) and nonresponders (23 patients). Results : Compared with responders, non-responders showed significantly elevated HMGB1 values. ROC analysis revealed an optimal cut-off value for HMGB1 for nonresponders. The sensitivity with high HMGB1 was 43% and accuracy 73%. When predicted non-responder is defined as a patient with Gunma score of 5 or over or high HMGB1 value, the sensitivity was 74% and accuracy 63%. Conclusion : Combinational use of HMGB1 value and Gunma score is useful for determine the severity of KD as the prediction for nonresponder of IVIG.
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