2010 Fiscal Year Final Research Report
The effects of maternal undernutrition and glucocorticoid on nephrogenesis
| Project/Area Number |
20591286
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Keio University |
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Principal Investigator |
AWAZU Midori Keio University, 医学部, 講師 (20129315)
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| Co-Investigator(Kenkyū-buntansha) |
HIDA Mariko 慶應義塾大学, 医学部, 共同研究員 (20276306)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 母体低栄養 / シグナル伝達 / ネフロン数 / プログラミング / 腎発生 / MAPキナーゼ / 尿管芽 / カスパーゼ3 |
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| Research Abstract |
Metanephros size and ureteric bud branching are decreased after embryonic day 14 by maternal nutrient restriction. Kidney size becomes normal after birth, whereas nephron number remains decreased. Signaling molecules important for kidney development are suppressed and activated at embryonic day 15 and 18, respectively. Cleaved caspase 3, a marker of apoptosis, was decreased at both time points. Inhibition of caspase 3 suppressed ureteric bud cell migration and cord formation. Low nephron number by maternal nutrient restriction results from inhibited ureteric branching that may be ascribed to the suppressed caspase 3 activity.
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