2010 Fiscal Year Final Research Report
Exploring New Anti-Cytokine Therapy for Kawasaki Disease
| Project/Area Number |
20591289
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nippon Medical School |
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Principal Investigator |
FUKAZAWA Ryuji Nippon Medical School, 医学部, 准教授 (80277566)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 小児循環器学 |
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| Research Abstract |
We tried to reveal cytokines action on very early stage of Kawasaki Disease (KD) by analyzing gene profiling in thrombocyte of Kawasaki disease patients. On very early stage of KD, the genes involving innate immunity and complement activation, such as Interleukin-1, Interleukin-18 and C1q, were significantly expressed. However, we could not detect complement activation in the serum of KD patients on admission. Analysis of Single Nucleotide Polymorphism about the genes involving innate immunity is on-going.
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